Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.93 |
| ▸ | RAB9A | P51151 | 10/20 | 0.93 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.93 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.62 |
| ▸ | RELA | Q04206 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | STAT1 | P42224 | 1/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | ACP1 | P24666 | 1/20 | 0.57 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6229810 | 0.96 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL6228337 | 0.91 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL1842324 | 0.85 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL2790542 | 0.85 | RAB9A (0.75) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL2792307 | 0.84 | NPC1 (0.78) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| Hydrochloric Acid SCHEMBL1844043 | 0.84 | NPC1 (0.97) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL2790525 | 0.83 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| Potassium Ion SCHEMBL2788878 | 0.82 | RAB9A (0.72) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL2792818 | 0.82 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 | |
| SCHEMBL2791120 | 0.82 | RAB9A (0.74) | NPC1RAB9ASMN1; SMN2ALDH1A1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9884839-B2 | Inhibitors of 17Beta-hydroxysteroid dehydrogenases type 1 and type 2 | ELEXOPHARM GMBH (DE) | 2018-02-06 | — | — | US | disclosed |
| EP-3089969-A2 | INHIBITORS OF 17BETA-HYDROXYSTEROID DEHYDROGENASES TYPE 1 AND TYPE 2 | Elexopharm GmbH (DE) | 2016-11-09 | — | — | EP | disclosed |
| US-20160318895-A1 | Inhibitors of 17Beta-Hydroxysteroid Dehydrogenases Type 1 and Type 2 | ELEXOPHARM GMBH (DE) | 2016-11-03 | — | — | US | disclosed |
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318895-A1 | Inhibitors of 17Beta-Hydroxysteroid Dehydrogenases Type 1 and Type 2 | HSD17B1, HSD17B2, HSD17B3 | NPC1 1349/4885RAB9A 4512/4885SMN1; SMN2 2537/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.