Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119255 | 1.00 | MEN1 (0.40) | MEN1KMT2AHTTMAPTMAPK1 | |
| SCHEMBL16166567 | 1.00 | MEN1 (0.40) | MEN1KMT2AHTTMAPTMAPK1 | |
| SCHEMBL26239587 | 0.83 | HTT (0.44) | MEN1KMT2AHTTMAPTMAPK1 | |
| SCHEMBL30917700 | 0.83 | HTT (0.44) | MEN1KMT2AHTTMAPTMAPK1 | |
| SCHEMBL6742837 | 0.83 | HTT (0.44) | MEN1KMT2AHTTMAPTMAPK1 | |
| SCHEMBL1345908 | 0.83 | HTT (0.44) | MEN1KMT2AHTTMAPTMAPK1 | |
| SCHEMBL14268018 | 0.83 | GABRA1 (0.46) | MEN1KMT2AHTTMAPTMAPK1 | |
| SCHEMBL31498780 | 0.83 | GABRA1 (0.46) | MEN1KMT2AHTTMAPTMAPK1 | |
| SCHEMBL28765431 | 0.81 | HTT (0.41) | MEN1KMT2AHTTMAPTMAPK1 | |
| SCHEMBL16961979 | 0.79 | HTT (0.39) | MEN1KMT2AHTTMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146037-A1 | PEPTIDYL NITRILE COMPOUND AND USE THEREOF | SHANGHAI YIDIAN PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD (CN) | 2026-05-28 | — | — | US | disclosed |
| US-20250101011-A1 | PEPTIDYL NITRILE COMPOUND AND USE THEREOF | SHANGHAI YIDIAN PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD (CN) | 2025-03-27 | — | — | US | disclosed |
| EP-4450497-A1 | PEPTIDYL NITRILE COMPOUND AND USE THEREOF | Shanghai Yidian Pharmaceutical Technology Development Co., Ltd (CN) | 2024-10-23 | — | — | EP | disclosed |
| CN-118475575-A | Peptidyl nitrile compound and application thereof | 上海壹典医药科技开发有限公司 | 2024-08-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250101011-A1 | PEPTIDYL NITRILE COMPOUND AND USE THEREOF | CTSC, CTSL, CTRL | MEN1 2152/4885KMT2A 4482/4885HTT 1002/4885 |
| US-20260146037-A1 | PEPTIDYL NITRILE COMPOUND AND USE THEREOF | JAK1, CTSZ, CTSL | MEN1 3993/4885KMT2A 1443/4885HTT 2895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.