Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.77 |
| ▸ | TSHR | P16473 | 4/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.77 |
| ▸ | GFER | P55789 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.65 |
| ▸ | RAB9A | P51151 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29918269 | 0.87 | KMT2A (1.00) | ALDH1A1TSHRKMT2ALMNAHSD17B10 | |
| SCHEMBL108225 | 0.85 | ALDH1A1 (0.90) | ALDH1A1TSHRKMT2ALMNAHSD17B10 | |
| SCHEMBL10341777 | 0.82 | HSP90AA1 (0.85) | ALDH1A1TSHRKMT2ALMNAHPGD | |
| SCHEMBL7972593 | 0.81 | ALDH1A1 (0.62) | ALDH1A1TSHRKMT2ALMNAHSD17B10 | |
| SCHEMBL10729478 | 0.81 | ALDH1A1 (1.00) | ALDH1A1TSHRKMT2ALMNAHSD17B10 | |
| SCHEMBL7263612 | 0.81 | ALDH1A1 (0.68) | ALDH1A1TSHRKMT2ALMNAHSD17B10 | |
| SCHEMBL5970063 | 0.79 | HPGD (1.00) | ALDH1A1TSHRKMT2ALMNAHSD17B10 | |
| SCHEMBL21535895 | 0.79 | KMT2A (1.00) | ALDH1A1TSHRKMT2ALMNAHSD17B10 | |
| SCHEMBL244547 | 0.78 | HPGD (1.00) | ALDH1A1TSHRKMT2ALMNAHSD17B10 | |
| SCHEMBL13486221 | 0.78 | HPGD (1.00) | ALDH1A1TSHRKMT2ALMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160009652-A1 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | UNIV ROCHESTER (US) | 2016-01-14 | — | — | US | claimed |
| US-20160009652-A1 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | UNIV ROCHESTER (US) | 2016-01-14 | — | — | US | disclosed |
| US-20160009652-A1 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | UNIV ROCHESTER (US) | 2016-01-14 | — | — | US | disclosed |
| US-20160009652-A1 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | UNIV ROCHESTER (US) | 2016-01-14 | — | — | US | disclosed |
| US-9162984-B2 | Small-molecule modulators of melanin expression | UNIVERSITY OF ROCHESTER (US) | 2015-10-20 | — | — | US | disclosed |
| US-9162984-B2 | Small-molecule modulators of melanin expression | UNIVERSITY OF ROCHESTER (US) | 2015-10-20 | — | — | US | disclosed |
| US-9162984-B2 | Small-molecule modulators of melanin expression | UNIVERSITY OF ROCHESTER (US) | 2015-10-20 | — | — | US | disclosed |
| US-20100233106-A1 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | UNIVERSITY OF ROCHESTER (US) | 2010-09-16 | — | — | US | disclosed |
| US-20100233106-A1 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | UNIVERSITY OF ROCHESTER (US) | 2010-09-16 | — | — | US | disclosed |
| US-20100233106-A1 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | UNIVERSITY OF ROCHESTER (US) | 2010-09-16 | — | — | US | disclosed |
| WO-2008121850-A2 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | UNIVERSITY OF ROCHESTER (US) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009652-A1 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | TYR, MITF, MC1R | ALDH1A1 737/4885TSHR 1470/4885KMT2A 2958/4885 |
| US-20100233106-A1 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | TYR, MITF, MC1R | ALDH1A1 737/4885TSHR 1470/4885KMT2A 2958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.