Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 5/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL108225 | 0.82 | ALDH1A1 (0.90) | ALDH1A1HSD17B10HPGDCYP2D6CYP1A2 | |
| SCHEMBL3104357 | 0.81 | ALDH1A1 (0.77) | ALDH1A1HSD17B10HPGDCYP2D6CYP1A2 | |
| SCHEMBL7968937 | 0.80 | MAPT (0.64) | ALDH1A1HSD17B10HPGDCYP2D6CYP1A2 | |
| SCHEMBL9185373 | 0.78 | CYP2D6 (0.62) | ALDH1A1CYP2D6KMT2AMEN1KDM4E | |
| SCHEMBL7970388 | 0.78 | CYP2D6 (0.62) | ALDH1A1CYP2D6KMT2APOLBMEN1 | |
| SCHEMBL7975189 | 0.78 | CYP2D6 (0.62) | ALDH1A1CYP2D6KMT2APOLBMEN1 | |
| SCHEMBL9192739 | 0.78 | TSHR (0.58) | ALDH1A1HSD17B10HPGDCYP2D6TSHR | |
| SCHEMBL7970184 | 0.77 | CYP2D6 (0.61) | ALDH1A1CYP2D6POLBKDM4E | |
| SCHEMBL14817973 | 0.77 | CYP2D6 (0.65) | ALDH1A1HPGDCYP2D6KMT2ALMNA | |
| SCHEMBL5970063 | 0.76 | HPGD (1.00) | ALDH1A1HSD17B10HPGDCYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6291464-B1 | POTENTIATION OF THE CHOLINERGIC ACTIVITY; THERAPEUTIC TREATMENT OF AMNESIA, DEMENTIA OR SENILE DEMENTIA | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| EP-0968201-A2 | NEW AMINOPIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998035951-A2 | NEW AMINOPIPERAZINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-08-20 | — | — | WO | disclosed |