Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.56 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.55 |
| ▸ | SIRT1 | Q96EB6 | 5/20 | 0.55 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.55 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MLKL | Q8NB16 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2445674 | 0.82 | HRH4 (0.53) | TDP1PKN1PKN2SIRT2SIRT1 | |
| SCHEMBL2445511 | 0.82 | GABRA1 (0.49) | PKN1PKN2SIRT2SIRT1SIRT3 | |
| SCHEMBL6472736 | 0.81 | HSP90AA1 (0.57) | HSP90AA1ESR2TDP1PIN1NPSR1 | |
| SCHEMBL3383861 | 0.79 | HSD17B10 (0.66) | HSP90AA1ESR2TDP1HRH3PKN1 | |
| SCHEMBL6169071 | 0.79 | PKN1 (0.67) | HSP90AA1ESR2TDP1PKN1PKN2 | |
| SCHEMBL4296230 | 0.79 | HSD17B10 (0.61) | NPSR1SMN1; SMN2ALDH1A1MAPK1 | |
| SCHEMBL13373678 | 0.79 | KDM4E (0.49) | TDP1PKN1PKN2SIRT2SIRT1 | |
| SCHEMBL12393006 | 0.78 | HRH3 (0.56) | HRH3PKN1PKN2SIRT2SIRT1 | |
| SCHEMBL11232099 | 0.78 | TUBB4A (0.59) | PKN1PKN2SIRT2SIRT1SIRT3 | |
| SCHEMBL2449514 | 0.78 | KCNJ1 (0.57) | TDP1SMN1; SMN2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7799806-B2 | Substituted n-benzyl piperidines as somatostatin receptor modulators | HOFFMANN-LA ROCHE INC. (US) | 2010-09-21 | — | — | US | disclosed |
| US-20080249101-A1 | BENZOIMIDAZOLE, TETRAHYDRO-QUINOXALINE, BENZOTRIAZOLE, DIHYDRO-IMIDAZO[4,5-c] PYRIDINONE AND DIHYDRO-ISOINDOLONE DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2008-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249101-A1 | BENZOIMIDAZOLE, TETRAHYDRO-QUINOXALINE, BENZOTRIAZOLE, DIHYDRO-IMIDAZO[4,5-c] PYRIDINONE AND DIHYDRO-ISOINDOLONE DERIVATIVES | SSTR5, SSTR3, SSTR1 | HSP90AA1 3661/4885ESR2 1011/4885TDP1 2911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.