Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.50 |
| ▸ | MLKL | Q8NB16 | 3/20 | 0.49 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.47 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6472733 | 0.89 | TDP1 (0.44) | HSP90AA1ESR2TDP1SMN1; SMN2NPSR1 | |
| SCHEMBL2557494 | 0.82 | HRH4 (0.53) | TDP1SMN1; SMN2PIN1APEX1ALDH1A1 | |
| SCHEMBL3104404 | 0.81 | HSP90AA1 (0.61) | HSP90AA1ESR2TDP1SMN1; SMN2NPSR1 | |
| SCHEMBL27552206 | 0.79 | XDH (0.52) | SMN1; SMN2NPSR1ALDH1A1MAPK1KDM4E | |
| SCHEMBL13217181 | 0.78 | ALDH1A1 (0.59) | TDP1SMN1; SMN2ALDH1A1MAPK1KDM4E | |
| SCHEMBL13217185 | 0.78 | ALDH1A1 (0.53) | TDP1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL31721205 | 0.78 | LCK (0.69) | HSP90AA1ESR2TDP1SMN1; SMN2NPSR1 | |
| SCHEMBL28845532 | 0.77 | HSP90AA1 (0.62) | HSP90AA1ESR2TDP1SMN1; SMN2NPSR1 | |
| SCHEMBL14336548 | 0.76 | SMN1; SMN2 (0.73) | HSP90AA1ESR2TDP1SMN1; SMN2NPSR1 | |
| SCHEMBL6947975 | 0.75 | HRH3 (0.52) | HSP90AA1ESR2TDP1SMN1; SMN2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005023986-A2 | MICRORNA AS LIGANDS AND TARGET MOLECULES | ISIS PHARMACEUTICALS, INC. (US) | 2005-03-17 | — | — | WO | disclosed |