Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MC3R | P41968 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28119175 | 1.00 | ADORA3 (0.36) | ADORA3TSHRMC4RADRA1AMC3R | |
| Trifluoroacetic Acid SCHEMBL28182510 | 0.89 | L3MBTL1 (0.38) | ADORA3TSHRMC4RADRA1AMC3R | |
| Trifluoroacetic Acid SCHEMBL30045250 | 0.89 | L3MBTL1 (0.38) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL733048 | 0.86 | ADORA3 (0.35) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL12548240 | 0.81 | KDM4E (0.41) | TSHRLMNAALDH1A1KMT2A | |
| SCHEMBL15145687 | 0.79 | ADORA3 (0.36) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL3917303 | 0.78 | ADORA3 (0.31) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL13544700 | 0.78 | ADORA3 (0.41) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL2492969 | 0.77 | TSHR (0.48) | ADORA3TSHRMC4RADRA1AMC3R | |
| SCHEMBL24993518 | 0.76 | NPSR1 (0.45) | TSHRLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240262795-A1 | PYRAZINE COMPOUNDS AS INHIBITORS OF FLT3 | BIOMEA FUSION, INC. | 2024-08-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240262795-A1 | PYRAZINE COMPOUNDS AS INHIBITORS OF FLT3 | FLT3, MCL1, CSF3R | ADORA3 3539/4885TSHR 2437/4885MC4R 4516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.