Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20670657 | 1.00 | KDM1A (0.34) | KDM1AMAOAMAOB | |
| SCHEMBL20670920 | 0.90 | — | — | |
| SCHEMBL14239873 | 0.87 | KDM1A (0.35) | KDM1AMAOAMAOB | |
| SCHEMBL20499969 | 0.79 | KDM1A (0.34) | KDM1AMAOAMAOB | |
| SCHEMBL20670909 | 0.79 | KDM1A (0.34) | KDM1AMAOAMAOB | |
| SCHEMBL28367039 | 0.79 | KDM1A (0.34) | KDM1AMAOAMAOB | |
| SCHEMBL3044092 | 0.75 | KDM1A (0.36) | KDM1AMAOAMAOB | |
| SCHEMBL12180331 | 0.75 | KDM1A (0.36) | KDM1AMAOAMAOB | |
| SCHEMBL12180325 | 0.75 | KDM1A (0.36) | KDM1AMAOAMAOB | |
| SCHEMBL5760976 | 0.75 | KCNH2 (0.42) | KDM1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260115185-A1 | QUINOLINE DERIVATIVES WHICH ACT AS KAPPA-OPIOID RECEPTOR ANTAGONISTS | SCRIPPS RESEARCH INST (US) | 2026-04-30 | — | — | US | disclosed |
| EP-4665455-A1 | QUINOLINE DERIVATIVES WHICH ACT AS KAPPA-OPIOID RECEPTOR ANTAGONISTS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173843-A1 | QUINOLINE DERIVATIVES WHICH ACT AS KAPPA-OPIOID RECEPTOR ANTAGONISTS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2024-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260115185-A1 | QUINOLINE DERIVATIVES WHICH ACT AS KAPPA-OPIOID RECEPTOR ANTAGONISTS | OPRK1, OPRD1, OPRM1 | KDM1A 1971/4885MAOA 614/4885MAOB 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.