Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSPB1 | P04792 | 2/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31224774 | 0.94 | PTGS1 (0.49) | TDP1ATMPTGS1PTGS2FFAR4 | |
| SCHEMBL12355282 | 0.93 | ATM (0.45) | TDP1ATMPTGS1PTGS2FFAR4 | |
| Hydrochloric Acid SCHEMBL29847893 | 0.89 | ATM (0.44) | TDP1ATMPTGS1PTGS2FFAR4 | |
| Hydrochloric Acid SCHEMBL16513834 | 0.89 | ATM (0.44) | TDP1ATMPTGS1PTGS2FFAR4 | |
| SCHEMBL12355287 | 0.88 | PTGS1 (0.43) | TDP1ATMPTGS1PTGS2FFAR4 | |
| SCHEMBL18824873 | 0.87 | ATM (0.46) | TDP1ATMPTGS1PTGS2FFAR4 | |
| SCHEMBL16532745 | 0.87 | ATM (0.43) | TDP1ATMPTGS1PTGS2FFAR4 | |
| SCHEMBL16514882 | 0.87 | MAOA (0.45) | TDP1ATMALDH1A1MAPTLMNA | |
| SCHEMBL12485845 | 0.84 | GPR119 (0.43) | TDP1ATMPTGS1PTGS2FFAR4 | |
| SCHEMBL19750865 | 0.84 | ATM (0.40) | TDP1ATMPTGS1PTGS2FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118359627-A | MTA synergistic PRMT5 inhibitor compounds having a tetracyclic fused ring structure | 烨辉医药科技(上海)有限公司 | 2024-07-19 | — | — | CN | disclosed |