Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | GPR174 | Q9BXC1 | 6/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31049358 | 0.93 | TDP1 (0.51) | ATMTDP1ALDH1A1MAPTLMNA | |
| SCHEMBL31224774 | 0.87 | PTGS1 (0.49) | ATMTDP1ALDH1A1MAPTGAA | |
| SCHEMBL12355287 | 0.84 | PTGS1 (0.43) | ATMTDP1ALDH1A1MAPTPTGS1 | |
| SCHEMBL18824873 | 0.84 | ATM (0.46) | ATMTDP1ALDH1A1MAPTGAA | |
| SCHEMBL16514882 | 0.84 | MAOA (0.45) | ATMTDP1ALDH1A1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL29847893 | 0.82 | ATM (0.44) | ATMTDP1ALDH1A1MAPTLMNA | |
| Hydrochloric Acid SCHEMBL16513834 | 0.82 | ATM (0.44) | ATMTDP1ALDH1A1MAPTLMNA | |
| SCHEMBL16532745 | 0.81 | ATM (0.43) | ATMTDP1ALDH1A1MAPTLMNA | |
| SCHEMBL2245628 | 0.80 | MAPT (0.50) | TDP1ALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL2241719 | 0.80 | MAPT (0.50) | TDP1ALDH1A1MAPTHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003676-B2 | 1,3,4-oxadiazole derivatives as DGAT1 inhibitors | ASTRAZENECA AB (SE) | 2011-08-23 | — | — | US | disclosed |
| US-20100029727-A1 | 1, 3, 4 -OXADIAZOLE DERIVATIVES AS DGAT1 INHIBITORS | ASTRAZENECA AB (SE) | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029727-A1 | 1, 3, 4 -OXADIAZOLE DERIVATIVES AS DGAT1 INHIBITORS | DGAT1, DGAT2, ACAT2 | ATM 2726/4885TDP1 2168/4885ALDH1A1 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.