Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.62 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | PNMT | P11086 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 6/20 | 0.52 |
| ▸ | NOS2 | P35228 | 6/20 | 0.52 |
| ▸ | NOS3 | P29474 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | CFD | P00746 | 2/20 | 0.49 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL15655272 | 0.91 | LOXL2 (0.56) | LOXL2ENPP2CYP1A2CYP2D6CYP2C9 | |
| Benzylamine SCHEMBL2841167 | 0.90 | LOXL2 (0.78) | LOXL2ENPP2CYP1A2CYP2D6CYP2C9 | |
| Benzylamine SCHEMBL2841170 | 0.90 | LOXL2 (0.78) | LOXL2ENPP2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL29809842 | 0.88 | PNMT (0.58) | LOXL2ENPP2CYP1A2CYP2D6CYP2C9 | |
| Benzylamine SCHEMBL25352130 | 0.87 | LOXL2 (0.74) | LOXL2ENPP2CYP1A2CYP2D6CYP2C9 | |
| Benzylamine SCHEMBL9567530 | 0.87 | LOXL2 (0.74) | LOXL2ENPP2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL3803115 | 0.87 | AKR1B1 (0.58) | LOXL2ENPP2CYP1A2CYP2D6CYP2C9 | |
| Bicarbonate SCHEMBL10634538 | 0.87 | MAOA (0.55) | LOXL2ENPP2CYP1A2CYP2D6CYP2C9 | |
| Terephthalic Acid SCHEMBL9858389 | 0.87 | LOXL2 (0.56) | LOXL2ENPP2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL10422276 | 0.87 | LOXL2 (0.71) | LOXL2ENPP2PNMTNOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118302406-A | Process for preparing diisocyanates | 韩华思路信(株) | 2024-07-05 | — | — | CN | claimed |
| CN-119907820-A | Isocyanate composition | 韩华思路信(株) | 2025-04-29 | — | — | CN | disclosed |
| CN-118302406-A | Process for preparing diisocyanates | 韩华思路信(株) | 2024-07-05 | — | — | CN | disclosed |