Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | DCK | P27707 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31578742 | 0.85 | SMN1; SMN2 (0.44) | SHMT2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL31057813 | 0.84 | MAPT (0.42) | SHMT2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL31578832 | 0.78 | SHMT2 (0.54) | SHMT2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL31578724 | 0.78 | SHMT2 (0.53) | SHMT2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL31578879 | 0.78 | SHMT2 (0.48) | SHMT2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL31578885 | 0.77 | SHMT2 (0.52) | SHMT2ALDH1A1KDM4EHPGDSHMT1 | |
| SCHEMBL31057952 | 0.76 | SHMT2 (0.52) | SHMT2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL31057737 | 0.75 | SHMT2 (0.52) | SHMT2ALDH1A1KDM4EGAAHPGD | |
| SCHEMBL31578791 | 0.74 | MAPK1 (0.45) | ALDH1A1KDM4EGAAHPGDSMN1; SMN2 | |
| SCHEMBL31057890 | 0.72 | SHMT2 (0.56) | SHMT2ALDH1A1KDM4EGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173718-A2 | HETEROBIFUNCTIONAL BINDERS OF KLHDC2 | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2024-08-22 | — | — | WO | disclosed |