Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 4/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31578838 | 0.88 | MEN1 (0.49) | JAK2JAK3SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31578770 | 0.85 | SHMT2 (0.61) | SHMT2SHMT1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31578724 | 0.85 | SHMT2 (0.53) | SHMT2SHMT1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31578832 | 0.83 | SHMT2 (0.54) | SHMT2SHMT1KDM4EALDH1A1MAPT | |
| SCHEMBL31578885 | 0.81 | SHMT2 (0.52) | SHMT2SHMT1KDM4EALDH1A1MAPT | |
| SCHEMBL31057887 | 0.78 | SHMT2 (0.44) | SHMT2SHMT1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31578704 | 0.78 | NPC1 (0.46) | SHMT2SHMT1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL31578742 | 0.77 | SMN1; SMN2 (0.44) | SHMT2SHMT1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20241556 | 0.74 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1MAPTGAAHPGD | |
| SCHEMBL31578923 | 0.74 | SHMT2 (0.55) | SHMT2SHMT1SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250163075-A1 | HETEROBIFUNCTIONAL TARGETED PROTEIN DEGRADERS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2025-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250163075-A1 | HETEROBIFUNCTIONAL TARGETED PROTEIN DEGRADERS | KLHDC2, KLHL6, KLHL20 | SHMT2 1737/4885JAK2 4153/4885JAK3 3850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.