Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 7/20 | 0.53 |
| ▸ | SHMT1 | P34896 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31058015 | 0.84 | SHMT2 (0.57) | SHMT2SHMT1ALDH1A1GAAEGLN1 | |
| SCHEMBL31057869 | 0.83 | SHMT2 (0.56) | SHMT2SHMT1ALDH1A1GAAEGLN1 | |
| SCHEMBL31057890 | 0.81 | SHMT2 (0.56) | SHMT2SHMT1ALDH1A1GAAEGLN1 | |
| SCHEMBL31057781 | 0.80 | SHMT2 (0.62) | SHMT2SHMT1ALDH1A1GAAEGLN1 | |
| SCHEMBL31057855 | 0.80 | SHMT2 (0.55) | SHMT2SHMT1ALDH1A1GAAEGLN1 | |
| SCHEMBL31057774 | 0.79 | SHMT2 (0.56) | SHMT2SHMT1ALDH1A1GAAEGLN1 | |
| SCHEMBL31057889 | 0.78 | SHMT1 (0.69) | SHMT2SHMT1ALDH1A1EGLN1HPGD | |
| SCHEMBL31057793 | 0.78 | SHMT2 (0.55) | SHMT2SHMT1ALDH1A1GAAEGLN1 | |
| SCHEMBL31057799 | 0.78 | SHMT2 (0.52) | SHMT2SHMT1ALDH1A1GAAEGLN1 | |
| SCHEMBL31057814 | 0.77 | SHMT2 (0.60) | SHMT2SHMT1ALDH1A1GAAEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024173718-A2 | HETEROBIFUNCTIONAL BINDERS OF KLHDC2 | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2024-08-22 | — | — | WO | disclosed |