Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.49 |
| ▸ | PPARA | Q07869 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16666722 | 0.89 | PPARG (0.49) | PPARGPPARAHDAC6HCRTR1HCRTR2 | |
| SCHEMBL6805662 | 0.85 | PPARG (0.47) | PPARGPPARAHDAC6HCRTR1HCRTR2 | |
| SCHEMBL14038386 | 0.85 | ELANE (0.49) | PPARGPPARAHCRTR1HCRTR2 | |
| SCHEMBL6799513 | 0.84 | PPARG (0.48) | PPARGPPARAHDAC6HCRTR1HCRTR2 | |
| SCHEMBL16676572 | 0.81 | PPARG (0.48) | PPARGPPARAHCRTR1HCRTR2NPC1 | |
| SCHEMBL9472948 | 0.80 | PPARG (0.57) | PPARGPPARAPPARD | |
| SCHEMBL8651094 | 0.80 | PPARG (0.50) | PPARGPPARAHDAC6HCRTR1HCRTR2 | |
| SCHEMBL5674725 | 0.80 | PPARG (0.50) | PPARGPPARAHDAC6HCRTR1HCRTR2 | |
| SCHEMBL9472944 | 0.79 | PPARG (0.56) | PPARGPPARA | |
| SCHEMBL9472938 | 0.79 | PPARG (0.56) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | XDH, GPR84, GPR88 | PPARG 402/4885PPARA 365/4885HDAC6 4240/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.