Caryophyllene

Caryophyllene

SCHEMBL310637

C=C1CC/C=C(/C)CC[C@@H]2[C@@H]1CC2(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 2/20 1.00
PPARA Q07869 2/20 1.00
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
CYP3A4 P08684 7/20 0.50
FTH1 P02794 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
USP2 O75604 1/20 0.45
PTGS1 P23219 1/20 0.41
TAS2R46 P59540 2/20 0.38
PKM P14618 2/20 0.38
RECQL P46063 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
TERT O14746 1/20 0.38
NLRP3 Q96P20 2/20 0.36
ALDH1A1 P00352 2/20 0.36
NFKB1 P19838 2/20 0.36
CASP1 P29466 1/20 0.36
PTGS2 P35354 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Beta-Caryophyllene SCHEMBL4195147 1.00 CNR2 (1.00) CNR2PPARAMEN1KMT2ACYP3A4
Beta-Caryophyllene SCHEMBL3505514 1.00 CNR2 (1.00) CNR2PPARAMEN1KMT2ACYP3A4
Beta-Caryophyllene SCHEMBL113830 1.00 CNR2 (1.00) CNR2PPARAMEN1KMT2ACYP3A4
Caryophyllene SCHEMBL4355327 1.00 CNR2 (1.00) CNR2PPARAMEN1KMT2ACYP3A4
Beta-Caryophyllene SCHEMBL4195140 1.00 CNR2 (1.00) CNR2PPARAMEN1KMT2ACYP3A4
Beta-Caryophyllene SCHEMBL4195149 1.00 CNR2 (1.00) CNR2PPARAMEN1KMT2ACYP3A4
Beta-Caryophyllene SCHEMBL24774027 1.00 CNR2 (1.00) CNR2PPARAMEN1KMT2ACYP3A4
Beta-Caryophyllene SCHEMBL1866747 1.00 CNR2 (1.00) CNR2PPARAMEN1KMT2ACYP3A4
Beta-Caryophyllene SCHEMBL22607973 1.00 CNR2 (1.00) CNR2PPARAMEN1KMT2ACYP3A4
Beta-Caryophyllene SCHEMBL29380416 1.00 CNR2 (1.00) CNR2PPARAMEN1KMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 586 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12357604-B2 Topical formulations of cannabinoids and use thereof in the treatment of pain INMED PHARMACEUTICALS INC. (CA) 2025-07-15 US claimed
WO-2025090929-A1 APPARATUS, SYSTEMS, AND METHODS FOR DETECTING HYPOGLYCEMIA THE TRUSTEES OF INDIANA UNIVERSITY (US) 2025-05-01 WO claimed
CN-113573592-B Coated mouth feel enhancer 味之素株式会社 2025-04-18 CN claimed
CN-119667037-A Method for separating and measuring borneol substances and related impurities by GC (gas chromatography) 上海博悦生物科技有限公司 2025-03-21 CN claimed
US-20250012013-A1 Kombucha Cellulose-based Derivative Refined from a Symbiotic Colony of Bacteria and Yeast KOMBUCHA BIOMATERIALS LLC 2025-01-09 US claimed
US-12083156-B1 Extracts derived from laser-irradiated rhizome of curcuma longa having enhanced antimicrobial activity King Faisal University (SA) 2024-09-10 US claimed
US-12042479-B2 Use of topical formulations of cannabinoids in the treatment of epidermolysis bullosa and related connective tissue disorders INMED PHARMACEUTICALS INC. 2024-07-23 US claimed
US-11903990-B2 Compositions and methods for treating and removing seborrheic keratoses STOECKER WILLIAM VAN DOVER (US) 2024-02-20 US claimed
EP-4257663-A1 FOOD CONTACT SURFACE SANITIZING LIQUID The Procter & Gamble Company (US) 2023-10-11 EP claimed
US-20230302026-A1 IMMUNOMODULATION FORMULATIONS AND RELATED METHODS VICKERS ALEXANDER (US) 2023-09-28 US claimed
US-20100166896-A1 METHODS FOR REPELLING INSECTS USING SESQUITERPENE HYDROCARBONS AND THEIR DERIVATIVES STERLING INTERNATIONAL INC. (US) 2010-07-01 US claimed
EP-2162128-A1 SESQUITERPENE FORMULATIONS, KITS AND METHODS OF USE THEREOF F.p.l. Pharma Inc. (CA) 2010-03-17 EP claimed
US-20090197949-A1 ANTITUMOR METHODS AND COMPOSITIONS COMPRISING SESQUITERPENE DERIVATIVES F.P.L. PHARMA, INC. (CA) 2009-08-06 US claimed
WO-2008144942-A1 SESQUITERPENE FORMULATIONS, KITS AND METHODS OF USE THEREOF F.P.L. PHARMA INC. (CA) 2008-12-04 WO claimed
EP-1372677-B1 USE OF COMPOSITIONS COMPRISING SESQUITERPENE DERIVATIVES FOR THE TREATMENT OF CANCER F P L PHARMA INC (CA) 2008-04-30 EP claimed
US-20040247669-A1 Long-lasting, flavored dosage forms for sustained release of beneficial agents within the mouth BENNES, INC. 2004-12-09 US claimed
US-20040191342-A1 Antitumor methods and compositions comprising sesquiterpene derivatives F.P.L. PHARMA INC. (CA) 2004-09-30 US claimed
US-20040151771-A1 Long-lasting, flavored dosage forms for sustained release of beneficial agents within the mouth BENNES, INC. 2004-08-05 US claimed
EP-1372677-A1 ANTITUMOR METHODS AND COMPOSITIONS COMPRISING SESQUITERPENE DERIVATIVES F.P.L. Pharma Inc. (CA) 2004-01-02 EP claimed
WO-2002078719-A1 ANTITUMOR METHODS AND COMPOSITIONS COMPRISING SESQUITERPENE DERIVATIVES F.P.L. PHARMA INC. (CA) 2002-10-10 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100166896-A1 METHODS FOR REPELLING INSECTS USING SESQUITERPENE HYDROCARBONS AND THEIR DERIVATIVES CYP51A1, LSS, DAGLA CNR2 425/4885PPARA 1267/4885MEN1 3334/4885
US-12357604-B2 Topical formulations of cannabinoids and use thereof in the treatment of pain CNR2, CNR1, LCAT CNR2 1/4885PPARA 46/4885MEN1 4039/4885
US-11903990-B2 Compositions and methods for treating and removing seborrheic keratoses CAT, CUTA, GPX1 CNR2 4467/4885PPARA 1261/4885MEN1 3487/4885
US-12042479-B2 Use of topical formulations of cannabinoids in the treatment of epidermolysis bullosa and related connective tissue disorders KRT18, DSP, DSC1 CNR2 28/4885PPARA 1391/4885MEN1 2431/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.