Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 14/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | SPR | P35270 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1748617 | 0.84 | RIPK1 (0.57) | RIPK1 | |
| SCHEMBL1777558 | 0.83 | RIPK1 (0.50) | RIPK1 | |
| SCHEMBL16493681 | 0.82 | RIPK1 (0.45) | RIPK1CDC7IGF1RCCNB2CDK1 | |
| SCHEMBL27714279 | 0.80 | RIPK1 (0.55) | RIPK1IGF1RCCNB2CDK1CCNB1 | |
| SCHEMBL5427263 | 0.80 | CDC7 (0.63) | HTR2CHTR2BHTR5ACDC7SPR | |
| SCHEMBL7168363 | 0.79 | RIPK1 (0.46) | RIPK1IGF1R | |
| SCHEMBL26174487 | 0.79 | RIPK1 (0.57) | RIPK1CDC7 | |
| SCHEMBL31064968 | 0.77 | RIPK1 (0.63) | RIPK1DAOIGF1RCCNB2CDK1 | |
| SCHEMBL1777660 | 0.74 | IGF1R (0.67) | RIPK1IGF1RCCNB2CDK1CCNB1 | |
| SCHEMBL3009852 | 0.73 | RIPK1 (0.74) | RIPK1DAOCCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1397360-A1 | AZAINDOLES | Aventis Pharma Limited (GB) | 2004-03-17 | — | — | EP | disclosed |
| WO-2003000688-A1 | AZAINDOLES | AVENTIS PHARMA LIMITED (GB) | 2003-01-03 | — | — | WO | disclosed |