Known targets — ChEMBL curated mechanism
CDK1CDK10CDK11BCDK12CDK13CDK14CDK15CDK16CDK17CDK18CDK19CDK2CDK20CDK3CDK4CDK5CDK6CDK7CDK8CDK9
The experimentally established mechanism targets of Pha-793887. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 known ✓ | P24941 | 20/20 | 0.98 |
| ▸ | CDK1 known ✓ | P06493 | 1/20 | 0.98 |
| ▸ | CDK4 known ✓ | P11802 | 1/20 | 0.98 |
| ▸ | CDK7 known ✓ | P50613 | 1/20 | 0.98 |
| ▸ | CDK9 known ✓ | P50750 | 1/20 | 0.98 |
| ▸ | CDK3 known ✓ | Q00526 | 1/20 | 0.98 |
| ▸ | CDK5 known ✓ | Q00535 | 1/20 | 0.98 |
| ▸ | CDK16 known ✓ | Q00536 | 1/20 | 0.98 |
| ▸ | CDK13 known ✓ | Q14004 | 1/20 | 0.98 |
| ▸ | CDK12 known ✓ | Q9NYV4 | 1/20 | 0.98 |
| ▸ | CCNA2 | P20248 | 20/20 | 0.98 |
| ▸ | CCNA1 | P78396 | 20/20 | 0.98 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.98 |
| ▸ | ULK1 | O75385 | 1/20 | 0.98 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.98 |
| ▸ | PAK4 | O96013 | 1/20 | 0.98 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.98 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.98 |
| ▸ | ERCC2 | P18074 | 1/20 | 0.98 |
| ▸ | CCND1 | P24385 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pha-793887 SCHEMBL5110328 | 0.99 | CCNA2 (1.00) | CCNA2CDK2CCNA1CCNT1ULK1 | |
| SCHEMBL24669470 | 0.87 | CCNA2 (0.82) | CCNA2CDK2CCNA1CCNT1ULK1 | |
| SCHEMBL22272113 | 0.82 | CCNA2 (0.78) | CCNA2CDK2CCNA1CCNT1ULK1 | |
| SCHEMBL25008205 | 0.79 | CCNA2 (0.66) | CCNA2CDK2CCNA1CCNT1ULK1 | |
| SCHEMBL24513389 | 0.78 | CCNA2 (0.66) | CCNA2CDK2CCNA1CCNT1ULK1 | |
| SCHEMBL28427761 | 0.75 | CCNA2 (0.61) | CCNA2CDK2CCNA1CCNT1ULK1 | |
| SCHEMBL24669016 | 0.74 | CCNA2 (0.59) | CCNA2CDK2CCNA1CCNT1ULK1 | |
| SCHEMBL28427763 | 0.73 | CCNA2 (0.59) | CCNA2CDK2CCNA1CCNT1ULK1 | |
| SCHEMBL22355618 | 0.72 | CCNA2 (0.54) | CCNA2CDK2CCNA1CCNT1ULK1 | |
| SCHEMBL15095340 | 0.71 | CDK2 (0.56) | CCNA2CDK2CCNA1CCNT1ULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240252688-A1 | COMPOSITIONS AND METHODS FOR ENHANCED PROTEIN PRODUCTION | HDT BIO CORP. | 2024-08-01 | — | — | US | disclosed |