SCHEMBL3107446

SCHEMBL3107446

O=C1C=Cc2ccccc2C1.[LiH]

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 1/20 0.43
GSK3B P49841 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP2A6 P11509 1/20 0.41
MAOA P21397 3/20 0.40
MAOB P27338 2/20 0.40
PARP1 P09874 1/20 0.38
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
TRPA1 O75762 1/20 0.36
CES1 P23141 3/20 0.35
BCHE P06276 2/20 0.35
MEN1 O00255 2/20 0.35
ALDH1A1 P00352 2/20 0.35
MAPT P10636 2/20 0.35
THRB P10828 2/20 0.35
ALOX15 P16050 2/20 0.35
KMT2A Q03164 2/20 0.35
HSD17B10 Q99714 2/20 0.35
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL461295 0.98 GSK3A (0.46) GSK3AGSK3BCYP1A2CYP2A6MAOA
SCHEMBL29421729 0.98 GSK3A (0.46) GSK3AGSK3BCYP1A2CYP2A6MAOA
SCHEMBL3102143 0.95 GSK3A (0.43) GSK3AGSK3BCYP1A2CYP2A6MAOA
SCHEMBL3106328 0.95 GSK3A (0.43) GSK3AGSK3BCYP1A2CYP2A6MAOA
SCHEMBL30579936 0.95 GSK3A (0.43) GSK3AGSK3BCYP1A2CYP2A6MAOA
Hydrochloric Acid SCHEMBL8917627 0.95 GSK3A (0.43) GSK3AGSK3BCYP1A2CYP2A6MAOA
SCHEMBL28090476 0.95 GSK3A (0.43) GSK3AGSK3BCYP1A2CYP2A6MAOA
SCHEMBL6517663 0.91 GSK3A (0.40) GSK3AGSK3BCYP1A2CYP2A6MAOA
SCHEMBL1793601 0.90 MAOA (0.41) GSK3AGSK3BCYP1A2CYP2A6MAOA
SCHEMBL283346 0.80 TRPA1 (0.50) CYP1A2MAOAMAOBPARP1CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5955609-A Trimer catalyst system for aliphatic and aromatic isocyanates BAYER CORPORATION (US) 1999-09-21 US claimed
US-9587060-B2 Functionalized rubbery polymers THE GOODYEAR TIRE & RUBBER COMPANY (US) 2017-03-07 US disclosed
US-8344171-B2 Process for making dihydrocarbyl hydrocarbonphosphonates ALBEMARLE CORPORATION (US) 2013-01-01 US disclosed
US-20100179342-A1 PROCESS FOR MAKING DIHYDROCARBYL HYDROCARBONPHOSPHONATES ALBEMARLE CORPORATION (US) 2010-07-15 US disclosed
US-7714089-B2 Functionalized monomers and functionalized rubbery polymers made therewith THE GOODYEAR TIRE & RUBBER COMPANY (US) 2010-05-11 US disclosed
EP-2164853-A1 PROCESS FOR MAKING DIHYDROCARBYL HYDROCARBONPHOSPHONATES Albermarle Corporation (US) 2010-03-24 EP disclosed
US-7572303-B2 A symmetrical dialkyl carbonate, a metal, borong, silicon, or group 7 compound, a hydrogen or hydrocarbon-based fuel, an oxidizer, and a metallic cocatalyst; minimized hydrolysis; improved combustion and storage stability OCTANE INTERNATIONAL, LTD. (US) 2009-08-11 US disclosed
US-7553963-B2 Liquid partially trimerized and allophanized polyisocyanates based on toluene diisocyanate and diphenylmethane diisocyanate BAYER MATERIALSCIENCE LLC (US) 2009-06-30 US disclosed
US-20090156769-A1 FUNCTIONALIZED MONOMERS AND FUNCTIONALIZED RUBBERY POLYMERS MADE THEREWITH THE GOODYEAR TIRE & RUBBER COMPANY 2009-06-18 US disclosed
WO-2008154268-A1 PROCESS FOR MAKING DIHYDROCARBYL HYDROCARBONPHOSPHONATES ALBEMARLE CORPORATION (US) 2008-12-18 WO disclosed
US-6028158-A Freeze-stable allophanate-modified toluene diisocyanate trimers BAYER CORPORATION (US) 2000-02-22 US disclosed
WO-1999066009-A2 FUEL COMPOSITIONS EMPLOYING CATALYST COMBUSTION STRUCTURE ORR WILLIAM C (US) 1999-12-23 WO disclosed
US-5955609-A Trimer catalyst system for aliphatic and aromatic isocyanates BAYER CORPORATION (US) 1999-09-21 US disclosed
US-5905151-A LITHIUM SALT AND ALCOHOL; CATALYTIC CYCLIZATION TO ISOCYANURIC ACID DERIVATIVES BAYER CORPORATION (US) 1999-05-18 US disclosed
US-5241104-A Reacting acid anhydride with arylacetic acid derivatives; for preparing optically active prostaglandins SHIONOGI & CO., LTD. (JP) 1993-08-31 US disclosed
EP-0373949-B1 MONO ESTERS OF DICARBOXYLIC ACIDS, THEIR PREPARATION AND USE SHIONOGI & CO (JP) 1993-08-25 EP disclosed
US-5183909-A Useful as intermediate for production of prostaglandins, terpenes, aminosugars, nucleotides and alkaloids SHIONOGI & COMPANY, LTD. (JP) 1993-02-02 US disclosed
US-5175341-A Bicyclo 2.2.2!heptanedicarboxylic acid derivatives SHIONOGI & CO., LTD. (JP) 1992-12-29 US disclosed
US-5047574-A CHEMICAL INTERMEDIATES FOR OPTICALLY ACTIVE PRODUCTS, MEDICINES SHIONOGI & CO., LTD. (JP) 1991-09-10 US disclosed
EP-0373949-A1 Mono esters of dicarboxylic acids, their preparation and use SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) 1990-06-20 EP disclosed