Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 10/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20017082 | 0.93 | PDK2 (0.36) | PDK2KMT2AATMGRM2 | |
| SCHEMBL21863425 | 0.92 | PDK2 (0.36) | PDK2KMT2AORAI1HPGD | |
| SCHEMBL871382 | 0.92 | PDK2 (0.36) | PDK2KMT2AORAI1HPGD | |
| SCHEMBL21247765 | 0.90 | KMT2A (0.39) | PDK2KMT2AATMGRM2 | |
| SCHEMBL20492209 | 0.89 | PDK2 (0.44) | PDK2HPGD | |
| SCHEMBL18415106 | 0.88 | KMT2A (0.36) | PDK2KMT2AATMHPGD | |
| SCHEMBL21863693 | 0.87 | PDK2 (0.39) | PDK2ORAI1HPGD | |
| SCHEMBL869547 | 0.87 | PDK2 (0.42) | PDK2KMT2AHPGD | |
| SCHEMBL3116329 | 0.86 | PDK2 (0.31) | PDK2HPGD | |
| SCHEMBL870417 | 0.86 | PDK2 (0.34) | PDK2GRM2ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9095138-B2 | Isoxazoline insecticides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2015-08-04 | — | — | US | disclosed |
| US-20150098928-A9 | ISOXAZOLINE INSECTICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2015-04-09 | — | — | US | disclosed |
| US-20140127165-A1 | ISOXAZOLINE INSECTICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-05-08 | — | — | US | disclosed |
| US-8623875-B2 | Isoxazoline insecticides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2014-01-07 | — | — | US | disclosed |
| EP-2155701-B1 | ISOXAZOLINE INSECTICIDES | DU PONT (US) | 2013-12-11 | — | — | EP | disclosed |
| US-20100179195-A1 | ISOXAZOLINE INSECTICIDES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2010-07-15 | — | — | US | disclosed |
| EP-2155701-A2 | ISOXAZOLINE INSECTICIDES | E. I. Du Pont de Nemours and Company (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008154528-A2 | ISOXAZOLINE INSECTICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150098928-A9 | ISOXAZOLINE INSECTICIDES | CBR3, CYP4X1, PRDX1 | PDK2 3141/4885KMT2A 3096/4885ATM 1526/4885 |
| US-20140127165-A1 | ISOXAZOLINE INSECTICIDES | CBR3, CYP4X1, PRDX1 | PDK2 3141/4885KMT2A 3096/4885ATM 1526/4885 |
| US-20100179195-A1 | ISOXAZOLINE INSECTICIDES | CBR3, CYP4X1, PRDX1 | PDK2 3141/4885KMT2A 3096/4885ATM 1526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.