Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 6/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | STAT1 | P42224 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.48 |
| ▸ | RELA | Q04206 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38662920 | 0.81 | MAPT (0.53) | GAAMAPTTP53NOTUM | |
| SCHEMBL4867095 | 0.79 | THRB (0.53) | HTTALDH1A1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL24898029 | 0.78 | NPC1 (0.61) | HTTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL38660957 | 0.76 | ROCK2 (0.42) | — | |
| SCHEMBL4866021 | 0.73 | POLB (0.57) | GAAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4866008 | 0.73 | POLB (0.57) | GAAALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31078071 | 0.72 | MAPK1 (0.43) | — | |
| SCHEMBL9799445 | 0.71 | NPC1 (0.67) | ALDH1A1NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL23000166 | 0.71 | MTOR (0.60) | GAANPC1 | |
| SCHEMBL27258764 | 0.71 | MTOR (0.56) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024140970-A1 | BICYCLIC COMPOUND, AND PREPARATION METHOD AND USE THEREFOR | 广州市联瑞制药有限公司 | 2024-07-04 | — | — | WO | disclosed |