Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23587190 | 0.87 | ROCK2 (0.50) | ROCK2ALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL23382867 | 0.86 | ROCK2 (0.49) | ROCK2ALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL31078524 | 0.86 | ROCK2 (0.49) | ROCK2ALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL31078911 | 0.84 | HSD11B1 (0.42) | ROCK2ALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL31078680 | 0.84 | ROCK2 (0.48) | ROCK2ALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL31078462 | 0.83 | HSD11B1 (0.42) | ROCK2ALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL31078544 | 0.77 | ROCK2 (0.54) | ROCK2ALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL31078568 | 0.76 | ROCK2 (0.48) | ROCK2ALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL31078503 | 0.76 | ROCK2 (0.46) | ROCK2ALDH1A1TSHRHSD17B10GAA | |
| SCHEMBL23732635 | 0.74 | ALDH1A1 (0.55) | ROCK2ALDH1A1TSHRHSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665733-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173323-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |