Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | STS | P08842 | 8/20 | 0.38 |
| ▸ | EED | O75530 | 1/20 | 0.38 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.38 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.38 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.38 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31078689 | 0.90 | PDE4B (0.39) | IKBKETBK1PDE4BNTRK1KCNH2 | |
| SCHEMBL31078515 | 0.84 | PDE4B (0.48) | PDE4BALDH1A1STSEEDRBBP4 | |
| SCHEMBL31078529 | 0.76 | GPR119 (0.45) | PDE4B | |
| SCHEMBL30590963 | 0.76 | PDE4B (0.46) | IKBKETBK1PDE4BNTRK1KCNH2 | |
| SCHEMBL31352847 | 0.76 | PDE4B (0.46) | IKBKETBK1PDE4BNTRK1KCNH2 | |
| SCHEMBL31078971 | 0.75 | ABHD6 (0.39) | PDE4BSTS | |
| SCHEMBL19527777 | 0.75 | PDE4B (0.43) | IKBKETBK1PDE4BNTRK1KCNH2 | |
| SCHEMBL31078846 | 0.74 | PDE4B (0.35) | PDE4BALDH1A1STSEEDRBBP4 | |
| SCHEMBL30590958 | 0.73 | PDE4B (0.44) | IKBKETBK1PDE4BSCN9AALDH1A1 | |
| SCHEMBL31078850 | 0.73 | LSS (0.44) | ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665733-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | Bristol-Myers Squibb Company (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173323-A1 | AMINO-SUBSTITUTED PYRROLOTRIAZINE DERIVATIVES AS INHIBITORS OF SGK1 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-08-22 | — | — | WO | disclosed |