Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.46 |
| ▸ | APLNR | P35414 | 4/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12261433 | 1.00 | GABRA1 (0.46) | GABRA1GABRB1APLNRDGAT1PYCR1 | |
| Methoxymethane SCHEMBL27923058 | 0.94 | APLNR (0.43) | GABRA1GABRB1APLNRDGAT1PYCR1 | |
| SCHEMBL15464206 | 0.84 | APLNR (0.38) | GABRA1GABRB1APLNRDGAT1PYCR1 | |
| SCHEMBL16545023 | 0.84 | APLNR (0.38) | GABRA1GABRB1APLNRDGAT1PYCR1 | |
| SCHEMBL14987514 | 0.83 | PDE2A (0.43) | GABRA1GABRB1APLNRDGAT1PYCR1 | |
| SCHEMBL20238210 | 0.83 | PDE2A (0.43) | GABRA1GABRB1APLNRDGAT1PYCR1 | |
| SCHEMBL18449424 | 0.83 | PDE2A (0.43) | GABRA1GABRB1APLNRDGAT1PYCR1 | |
| SCHEMBL1145058 | 0.83 | GABRA1 (0.39) | GABRA1GABRB1APLNRDGAT1PYCR1 | |
| SCHEMBL16960364 | 0.83 | APLNR (0.37) | GABRA1GABRB1APLNRDGAT1PYCR1 | |
| SCHEMBL28802581 | 0.83 | APLNR (0.37) | GABRA1GABRB1APLNRDGAT1PYCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | CMPK1, WNK1, AAK1 | GABRA1 3621/4885GABRB1 4016/4885APLNR 3339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.