Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 3/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.38 |
| ▸ | GPR6 | P46095 | 5/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.37 |
| ▸ | FEN1 | P39748 | 2/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | CCND3 | P30281 | 1/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29964617 | 0.92 | MAPKAPK2 (0.40) | MAPK1GSK3BIKBKBCHUKPARP10 | |
| SCHEMBL29964212 | 0.91 | TBK1 (0.43) | MAPK1 | |
| SCHEMBL31079210 | 0.91 | MAPK1 (0.39) | MAPK1GSK3BIKBKBCHUKPARP10 | |
| SCHEMBL29964484 | 0.90 | CHEK2 (0.44) | MAPK1GSK3BIKBKBCHUKPARP10 | |
| SCHEMBL31079292 | 0.90 | GPR119 (0.46) | MAPK1GSK3BALOX5APFEN1 | |
| SCHEMBL29964129 | 0.90 | MAPK1 (0.38) | MAPK1GSK3BIKBKBCHUKPARP10 | |
| SCHEMBL31079217 | 0.88 | MAPK1 (0.41) | MAPK1GSK3BPARP10PARP11MAPKAPK2 | |
| SCHEMBL31078998 | 0.88 | MAPK1 (0.39) | MAPK1GSK3BIKBKBCHUKPARP10 | |
| SCHEMBL29964382 | 0.87 | ALOX5AP (0.45) | MAPK1GSK3BIKBKBCHUKPARP10 | |
| SCHEMBL31079274 | 0.86 | MAPKAPK2 (0.40) | MAPK1GSK3BIKBKBCHUKPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2024-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240343704-A1 | HALO-SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | CMPK1, WNK1, AAK1 | MAPK1 141/4885GSK3B 1000/4885IKBKB 655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.