Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 12/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 11/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1461371 | 0.78 | CYP1A2 (0.52) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL8815628 | 0.73 | GAA (0.50) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL17336600 | 0.72 | MAPT (0.76) | MAPT | |
| SCHEMBL25614496 | 0.72 | CYP3A4 (0.42) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL23055298 | 0.70 | CYP3A4 (0.53) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL10162595 | 0.70 | LOXL2 (0.47) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL4878557 | 0.69 | LMNA (0.56) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL21863403 | 0.69 | CYP3A4 (0.46) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL30753599 | 0.69 | LMNA (0.56) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 | |
| SCHEMBL28678423 | 0.69 | CYP3A4 (0.59) | MAPTCYP1A2CYP3A4CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4676547-A2 | ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2026-01-14 | — | — | EP | disclosed |
| WO-2024186584-A2 | ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-09-12 | — | — | WO | disclosed |