Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31493462 | 0.84 | POLB (0.44) | HPGDKMT2A | |
| SCHEMBL15219373 | 0.73 | SIGMAR1 (0.53) | SIGMAR1HPGDRXFP1HTR2CHRH4 | |
| SCHEMBL31514405 | 0.73 | MEN1 (0.45) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL31737420 | 0.71 | HTR2C (0.50) | HPGDHTR2CHRH4KMT2A | |
| Hydrochloric Acid SCHEMBL31737360 | 0.70 | HTR2C (0.49) | HTR2CKMT2A | |
| SCHEMBL4661842 | 0.70 | PDE10A (0.49) | SIGMAR1RXFP1HRH4MKNK2MKNK1 | |
| SCHEMBL14029794 | 0.70 | PARP1 (0.45) | SIGMAR1BRD4HPGDHSP90AA1HTR2C | |
| SCHEMBL28061258 | 0.70 | HTR2C (0.56) | SIGMAR1HTR2CHRH4 | |
| SCHEMBL13647306 | 0.69 | KMO (0.44) | HPGDKMT2APKM | |
| SCHEMBL31289904 | 0.69 | KMO (0.44) | HPGDKMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528806-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-12421233-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-09-23 | — | — | US | disclosed |
| US-12344609-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-07-01 | — | — | US | disclosed |
| US-20250171442-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171441-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171440-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| CN-119899186-A | Azabicyclo derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2025-04-29 | — | — | CN | disclosed |
| US-20250034136-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-01-30 | — | — | US | disclosed |
| WO-2024153244-A1 | NITROGEN-CONTAINING COMPOUND | 南京再明医药有限公司 | 2024-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250171440-A1 | WRN INHIBITORS | WRN, BLM, RECQL | SIGMAR1 4746/4885BRD4 1594/4885HPGD 1803/4885 |
| US-20250171441-A1 | WRN INHIBITORS | WRN, BLM, RECQL | SIGMAR1 4650/4885BRD4 1480/4885HPGD 1716/4885 |
| US-12421233-B2 | WRN inhibitors | WRN, BLM, RECQL | SIGMAR1 4650/4885BRD4 1480/4885HPGD 1716/4885 |
| US-12344609-B2 | WRN inhibitors | WRN, BLM, RECQL | SIGMAR1 4746/4885BRD4 1594/4885HPGD 1803/4885 |
| US-20250034136-A1 | WRN INHIBITORS | WRN, BLM, RECQL | SIGMAR1 4650/4885BRD4 1480/4885HPGD 1716/4885 |
| US-20250171442-A1 | WRN INHIBITORS | WRN, BLM, RECQL | SIGMAR1 4663/4885BRD4 1569/4885HPGD 1631/4885 |
| US-12528806-B2 | WRN inhibitors | WRN, RECQL, BLM | SIGMAR1 4304/4885BRD4 1029/4885HPGD 1748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.