Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA2 | P00918 | 2/20 | 0.54 |
| ▸ | CA9 | Q16790 | 2/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | IDH1 | O75874 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 1/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22057590 | 1.00 | ALDH1A1 (0.59) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL13170074 | 0.87 | MEN1 (0.60) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL21394362 | 0.87 | TMPRSS4 (0.57) | ALDH1A1MAPTCYP1A2CYP2C19MEN1 | |
| SCHEMBL2080632 | 0.86 | SMN1; SMN2 (0.58) | ALDH1A1MAPTCA1CA2CA9 | |
| SCHEMBL3878977 | 0.85 | CA1 (0.54) | ALDH1A1MAPTCYP2C19CA1CA2 | |
| SCHEMBL9824604 | 0.84 | ALDH1A1 (0.59) | ALDH1A1MAPTCYP1A2CYP2C19CA1 | |
| SCHEMBL8346848 | 0.84 | MAPT (0.56) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL27672060 | 0.83 | ALDH1A1 (0.63) | ALDH1A1MAPTCYP1A2CYP2C19CA1 | |
| SCHEMBL20428900 | 0.83 | PDK1 (0.48) | ALDH1A1MAPTCA1CA2CA9 | |
| SCHEMBL31245754 | 0.83 | CYP1A2 (0.57) | ALDH1A1MAPTCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12528806-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2026-01-20 | — | — | US | disclosed |
| US-12421233-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-09-23 | — | — | US | disclosed |
| US-12344609-B2 | WRN inhibitors | NIMBUS WADJET, INC. (US) | 2025-07-01 | — | — | US | disclosed |
| US-20250171442-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20250171441-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-05-29 | — | — | US | disclosed |
| WO-2025087274-A1 | AZABICYCLO DERIVATIVE AND PREPARATION METHOD THEREFOR, AND USE | 浙江海正药业股份有限公司 | 2025-05-01 | — | — | WO | disclosed |
| CN-119899186-A | Azabicyclo derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2025-04-29 | — | — | CN | disclosed |
| US-20250129069-A1 | TRIAZOLO WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-04-24 | — | — | US | disclosed |
| WO-2025049746-A1 | COMPOSITIONS COMPRISING WERNER SYNDROME HELICASE INHIBITORS AND METHODS OF USING THE SAME | EIKON THERAPEUTICS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |
| WO-2025045145-A1 | WRN HELICASE-INHIBITING BIS-HETEROCYCLIC DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USE THEREOF | 广州科恩泰生物医药科技有限公司 | 2025-03-06 | — | — | WO | disclosed |
| US-20250034136-A1 | WRN INHIBITORS | NIMBUS WADJET, INC. | 2025-01-30 | — | — | US | disclosed |
| WO-2024153244-A1 | NITROGEN-CONTAINING COMPOUND | 南京再明医药有限公司 | 2024-07-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250171441-A1 | WRN INHIBITORS | WRN, BLM, RECQL | ALDH1A1 3002/4885MAPT 3795/4885CYP1A2 4380/4885 |
| US-12421233-B2 | WRN inhibitors | WRN, BLM, RECQL | ALDH1A1 3002/4885MAPT 3795/4885CYP1A2 4380/4885 |
| US-12344609-B2 | WRN inhibitors | WRN, BLM, RECQL | ALDH1A1 3196/4885MAPT 3802/4885CYP1A2 4034/4885 |
| US-20250034136-A1 | WRN INHIBITORS | WRN, BLM, RECQL | ALDH1A1 3002/4885MAPT 3795/4885CYP1A2 4380/4885 |
| US-20250129069-A1 | TRIAZOLO WRN INHIBITORS | WRN, BLM, RECQL | ALDH1A1 3394/4885MAPT 3570/4885CYP1A2 4216/4885 |
| US-20250171442-A1 | WRN INHIBITORS | WRN, BLM, RECQL | ALDH1A1 2905/4885MAPT 3825/4885CYP1A2 4332/4885 |
| US-12528806-B2 | WRN inhibitors | WRN, RECQL, BLM | ALDH1A1 1817/4885MAPT 3335/4885CYP1A2 4442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.