Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.39 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17696931 | 0.83 | DPP4 (0.42) | CYP3A4MAPK1DPP4HSD17B10TSHR | |
| SCHEMBL17107575 | 0.81 | CYP3A4 (0.48) | CYP3A4MAPK1HSD17B10TSHRALDH1A1 | |
| SCHEMBL911858 | 0.79 | CYP3A4 (0.59) | CYP3A4MAPK1HSD17B10TSHRALDH1A1 | |
| SCHEMBL29782293 | 0.79 | CYP3A4 (0.59) | CYP3A4MAPK1HSD17B10TSHRALDH1A1 | |
| SCHEMBL12902973 | 0.75 | CYP3A4 (0.42) | CYP3A4MAPK1HSD17B10TSHRALDH1A1 | |
| SCHEMBL118745 | 0.75 | MEP1A (0.40) | CYP3A4MAPK1DPP4HSD17B10TSHR | |
| SCHEMBL27411750 | 0.75 | CYP3A4 (0.42) | CYP3A4MAPK1HSD17B10TSHRALDH1A1 | |
| SCHEMBL529908 | 0.75 | HTR2B (0.39) | CYP3A4MAPK1DPP4HSD17B10ALDH1A1 | |
| SCHEMBL7460667 | 0.75 | CA1 (0.43) | CYP3A4MAPK1DPP4HSD17B10TSHR | |
| SCHEMBL19474727 | 0.75 | DPP4 (0.37) | CYP3A4MAPK1DPP4HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2236508-B1 | Reactive Heterocycle-Substituted 7-Hydroxycoumarins and Their Conjugates | BECTON DICKINSON CO (US) | 2015-08-26 | — | — | EP | disclosed |
| US-8431416-B2 | Reactive heterocycle-substituted 7-hydroxycoumarins and their conjugates | BECTON, DICKINSON AND COMPANY (US) | 2013-04-30 | — | — | US | disclosed |
| US-8318953-B2 | Reactive coumarin derivatives and their use in cellular analyses | AAT BIOQUEST, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20110318772-A1 | REACTIVE COUMARIN DERIVATIVES AND THEIR USE IN CELLULAR ANALYSES | AAT BIOQUEST, INC. (US) | 2011-12-29 | — | — | US | disclosed |
| CN-101270105-B | Coumarin compound for enzymatic activity analysis and enzyme inhibitor sifting motion, and synthesizing process | DESUO YANG | 2011-09-14 | — | — | CN | disclosed |
| US-20100255504-A1 | Reactive Heterocycle-Substituted 7-Hydroxycoumarins and Their Conjugates | BECTON, DICKINSON AND COMPANY (US) | 2010-10-07 | — | — | US | disclosed |
| EP-2236508-A1 | Reactive Heterocycle-Substituted 7-Hydroxycoumarins and Their Conjugates | Becton, Dickinson and Company (US) | 2010-10-06 | — | — | EP | disclosed |
| CN-101270105-A | Coumarin compound for enzymatic activity analysis and enzyme inhibitor sifting motion, and synthesizing process | DESUO YANG (CN) | 2008-09-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110318772-A1 | REACTIVE COUMARIN DERIVATIVES AND THEIR USE IN CELLULAR ANALYSES | CYP3A7, XPO7, HCCS | CYP3A4 11/4885MAPK1 2217/4885DPP4 2958/4885 |
| US-20100255504-A1 | Reactive Heterocycle-Substituted 7-Hydroxycoumarins and Their Conjugates | HLCS, CD44, HCCS | CYP3A4 71/4885MAPK1 4456/4885DPP4 4479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.