Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 2/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.33 |
| ▸ | TCF7 | P36402 | 1/20 | 0.33 |
| ▸ | CDH1 | P12830 | 1/20 | 0.33 |
| ▸ | TCF4 | P15884 | 1/20 | 0.33 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23309033 | 0.84 | HDAC8 (0.52) | HDAC8HTR2AHTR2CCYP1A2TGFBR1 | |
| SCHEMBL15910951 | 0.78 | CHEK1 (0.49) | HDAC8HTR2AHTR2CCYP1A2TGFBR1 | |
| SCHEMBL30168569 | 0.78 | CHEK1 (0.49) | HDAC8HTR2AHTR2CCYP1A2TGFBR1 | |
| SCHEMBL29728749 | 0.75 | CTNNB1 (0.54) | HTR2ACACNA1HCTNNB1TCF7 | |
| SCHEMBL904751 | 0.75 | CTNNB1 (0.54) | HTR2ACACNA1HCTNNB1TCF7 | |
| SCHEMBL23886616 | 0.75 | HDAC8 (0.48) | HDAC8HTR2AHTR2CCYP1A2TGFBR1 | |
| SCHEMBL21509551 | 0.72 | NR3C1 (0.38) | HDAC8HTR2AHTR2CCYP1A2TGFBR1 | |
| SCHEMBL904745 | 0.72 | HTR2A (0.43) | HTR2AHTR2CCACNA1HCTNNB1TCF7 | |
| SCHEMBL23904599 | 0.72 | SCN9A (0.44) | HDAC8CYP1A2TGFBR1 | |
| SCHEMBL24338731 | 0.71 | HDAC8 (0.41) | HDAC8HTR2AHTR2CCA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240294498-A1 | FACTOR XIIA INHIBITORS | LUNAC THERAPEUTICS LTD (GB) | 2024-09-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240294498-A1 | FACTOR XIIA INHIBITORS | F11, F13B, F7 | HDAC8 531/4885HTR2A 4483/4885HTR2C 4658/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.