Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CCR2 | P41597 | 3/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 6/20 | 0.38 |
| ▸ | SSTR1 | P30872 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL829866 | 0.88 | KDM4E (0.41) | NTRK1KDM4EALDH1A1HPGDIDO1 | |
| SCHEMBL832123 | 0.77 | ALDH1A1 (0.42) | KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3110734 | 0.77 | NTRK1 (0.48) | NTRK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL21647634 | 0.74 | ALDH1A1 (0.61) | NTRK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3114834 | 0.73 | ALDH1A1 (0.50) | NTRK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL3114034 | 0.73 | CCR2 (0.53) | NTRK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4600229 | 0.71 | CCR2 (0.56) | NTRK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4599686 | 0.70 | IDO1 (0.61) | NTRK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL15362104 | 0.70 | CCR2 (0.53) | NTRK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4600138 | 0.70 | CCR2 (0.53) | NTRK1KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987010-B1 | TRICYCLIC N-HETEROARYL-CARBOXAMIDE DERIVATIVES CONTAINING A BENZIMIDAZOLE UNIT, METHOD FOR PREPARING SAME AND THEIR THERAPEUTIC USE | SANOFI AVENTIS (FR) | 2010-04-07 | — | — | EP | disclosed |
| EP-1987010-A1 | TRICYCLIC N-HETEROARYL-CARBOXAMIDE DERIVATIVES CONTAINING A BENZIMIDAZOLE UNIT, METHOD FOR PREPARING SAME AND THEIR THERAPEUTIC USE | Sanofi-Aventis (FR) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007088277-A1 | TRICYCLIC Ν-HETEROARYL-CARBOXAMIDE DERIVATIVES CONTAINING A BENZIMIDAZOLE UNIT, METHOD FOR PREPARING SAME AND THEIR THERAPEUTIC USE | SANOFI-AVENTIS (FR) | 2007-08-09 | — | — | WO | disclosed |