Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 9/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.46 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30622510 | 0.86 | CCR2 (0.55) | CCR2NTRK1GPR35 | |
| SCHEMBL20604983 | 0.86 | CCR2 (0.65) | CCR2NTRK1ALDH1A1GPR35 | |
| SCHEMBL30622493 | 0.86 | CCR2 (0.65) | CCR2NTRK1ALDH1A1GPR35 | |
| SCHEMBL31300732 | 0.85 | GPR35 (0.48) | CCR2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL4600098 | 0.84 | CCR2 (0.55) | CCR2NTRK1KDM4EALDH1A1HPGD | |
| SCHEMBL4599709 | 0.84 | CCR2 (0.55) | CCR2NTRK1KDM4EALDH1A1HPGD | |
| SCHEMBL4600347 | 0.84 | CCR2 (0.55) | CCR2NTRK1KDM4EALDH1A1HPGD | |
| SCHEMBL3615699 | 0.84 | NOD2 (0.51) | NTRK1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL15361967 | 0.82 | CCR2 (0.53) | CCR2NTRK1KDM4EALDH1A1HPGD | |
| SCHEMBL30547723 | 0.82 | CCR2 (0.45) | CCR2GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910335-B1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | SANOFI SA (FR) | 2013-11-06 | — | — | EP | claimed |
| EP-1910335-A1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2008-04-16 | — | — | EP | claimed |
| WO-2007010144-A1 | N-(HETEROARYL)-1-HETEROARYLALKYL-1H-INDOLE-2-CARBOXAMIDE DERIVATIVES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2007-01-25 | — | — | WO | claimed |