Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | FRK | P42685 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26453168 | 0.88 | DGAT1 (0.37) | DGAT1MAPT | |
| SCHEMBL19806627 | 0.87 | DGAT1 (0.37) | DGAT1MAPTCSNK1DMAP4K4EGFR | |
| SCHEMBL19806313 | 0.87 | DGAT1 (0.41) | DGAT1MAPTMAPK14MAPK1CSNK1D | |
| SCHEMBL2608746 | 0.85 | ALDH1A1 (0.40) | DGAT1MAPTMAPK1NPSR1CYP3A4 | |
| SCHEMBL31074565 | 0.84 | MAPK14 (0.34) | DGAT1MAPTMAPK14BRAFMAPK1 | |
| SCHEMBL29280467 | 0.80 | BRAF (0.44) | MAPK14BRAFMAPK1MAPK3CSNK1D | |
| SCHEMBL19806359 | 0.79 | DGAT1 (0.38) | DGAT1MAPK14MAP4K4 | |
| SCHEMBL31074535 | 0.79 | CYP11B1 (0.35) | MAPTMAPK14BRAFCSNK1DMAPK13 | |
| SCHEMBL19806555 | 0.78 | NPC1 (0.40) | DGAT1MAPTMAPK14 | |
| SCHEMBL26684293 | 0.77 | DGAT1 (0.40) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024227104-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BRAF VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2024-10-31 | — | — | WO | disclosed |