Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | PPOX | P50336 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1223997 | 1.00 | NPC1 (0.45) | NPC1GAATAAR1POLBPPOX | |
| SCHEMBL1552822 | 0.92 | GAA (0.45) | NPC1GAATAAR1POLBPPOX | |
| SCHEMBL20158042 | 0.83 | POLB (0.42) | NPC1GAATAAR1POLBPPOX | |
| SCHEMBL16068694 | 0.83 | L3MBTL1 (0.42) | NPC1L3MBTL1MAPTRAB9ALMNA | |
| SCHEMBL4573417 | 0.82 | PRKDC (0.48) | TAAR1POLBL3MBTL1MAPTNPSR1 | |
| SCHEMBL30888547 | 0.82 | POLB (0.54) | NPC1GAATAAR1POLBL3MBTL1 | |
| SCHEMBL31085113 | 0.82 | PRKDC (0.48) | TAAR1POLBL3MBTL1MAPTNPSR1 | |
| SCHEMBL16068845 | 0.81 | RAB9A (0.38) | NPC1GAAPOLBL3MBTL1MAPT | |
| SCHEMBL16068857 | 0.81 | TTR (0.50) | MAPTLMNAHSP90AA1 | |
| SCHEMBL16069089 | 0.81 | NPBWR1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4524139-A1 | IMIDAZOPYRIDAZINE SUBSTITUTED BENZENE RING DERIVATIVE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | Shanghai Simr Biotechnology Co., Ltd. (CN) | 2025-03-19 | — | — | EP | disclosed |
| WO-2024192147-A2 | PROTOPORPHYRINOGEN OXIDASE INHIBITORS | ENKO CHEM, INC. (US) | 2024-09-19 | — | — | WO | disclosed |