SCHEMBL31124696

SCHEMBL31124696

O=Cc1cccc(C(F)F)c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.48
UNG P13051 1/20 0.44
CYP2A6 P11509 1/20 0.42
TYR P14679 1/20 0.40
SRC P12931 1/20 0.39
DRD1 P21728 1/20 0.39
TRIM24 O15164 1/20 0.38
TRIM33 Q9UPN9 1/20 0.38
MAOA P21397 3/20 0.38
MAOB P27338 3/20 0.38
CA12 O43570 1/20 0.37
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37
CA9 Q16790 1/20 0.37
NOTUM Q6P988 1/20 0.37
PGK1 P00558 1/20 0.36
PGK2 P07205 1/20 0.36
KDM4E B2RXH2 1/20 0.35
PTGS2 P35354 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2263076 1.00 ALDH1A1 (0.48) ALDH1A1UNGCYP2A6TYRSRC
SCHEMBL7141606 0.83 ALDH1A1 (0.45) ALDH1A1UNGCYP2A6TYRSRC
SCHEMBL30291836 0.83 TYR (0.56) ALDH1A1UNGCYP2A6TYRSRC
SCHEMBL727874 0.83 TYR (0.56) ALDH1A1UNGCYP2A6TYRSRC
SCHEMBL2536000 0.82 ALDH1A1 (0.48) ALDH1A1UNGCYP2A6SRCDRD1
SCHEMBL29756201 0.79 ALDH1A1 (0.50) ALDH1A1UNGCYP2A6TYRSRC
SCHEMBL4950119 0.78 ALDH1A1 (0.48) ALDH1A1UNGCYP2A6TYRSRC
SCHEMBL4952311 0.78 ALDH1A1 (0.48) ALDH1A1UNGCYP2A6TYRSRC
SCHEMBL4808239 0.78 ALDH1A1 (0.48) ALDH1A1UNGCYP2A6TYRSRC
SCHEMBL2937253 0.78 ALDH1A1 (0.48) ALDH1A1UNGCYP2A6TYRSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113382767-B Urea compounds having substituents 第一三共株式会社 2024-12-24 CN disclosed
CN-118724903-A Compound with fused ring structure, its preparation method and use, and pharmaceutical composition and use 苏州安赛隆医药科技有限公司 2024-10-01 CN disclosed