Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31127800 | 1.00 | MAPT (0.45) | MAPTALDH1A1KMT2ATDP1CASP3 | |
| SCHEMBL13606743 | 0.82 | MAPT (0.45) | MAPTALDH1A1KMT2ATDP1MAPK1 | |
| SCHEMBL27183548 | 0.81 | HTT (0.50) | MAPTALDH1A1KMT2ATDP1MAPK1 | |
| SCHEMBL31154857 | 0.81 | MAPT (0.58) | MAPTALDH1A1KMT2ATDP1MAPK1 | |
| SCHEMBL3823602 | 0.81 | MAPT (0.58) | MAPTALDH1A1KMT2ATDP1MAPK1 | |
| SCHEMBL34461285 | 0.81 | MAOA (0.51) | MAPTALDH1A1KMT2ATDP1MAPK1 | |
| SCHEMBL13019970 | 0.81 | MAPT (0.58) | MAPTALDH1A1KMT2ATDP1MAPK1 | |
| SCHEMBL31048348 | 0.81 | MAPT (0.58) | MAPTALDH1A1KMT2ATDP1MAPK1 | |
| SCHEMBL30846780 | 0.81 | HTT (0.50) | MAPTALDH1A1KMT2ATDP1MAPK1 | |
| SCHEMBL23977249 | 0.78 | CYP11B2 (0.40) | MAPTALDH1A1KMT2ATDP1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688788-A1 | PYRIDO[4,3-D]PYRIMIDINE COMPOUNDS | Pfizer Inc. (US) | 2026-02-11 | — | — | EP | disclosed |
| US-12281127-B2 | Pyrido[4,3-d]pyrimidine compounds | PFIZER INC. (US) | 2025-04-22 | — | — | US | disclosed |
| US-20250034173-A1 | PYRIDO[4,3-D]PYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2025-01-30 | — | — | US | disclosed |
| WO-2024209339-A1 | PYRIDO[4,3-D]PYRIMIDINE COMPOUNDS | PFIZER INC. (US) | 2024-10-10 | — | — | WO | disclosed |
| US-20240336631-A1 | Pyrido[4,3-d]pyrimidine Compounds | PFIZER INC. (US) | 2024-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240336631-A1 | Pyrido[4,3-d]pyrimidine Compounds | DPYD, PNPO, TYMP | MAPT 2869/4885ALDH1A1 436/4885KMT2A 3609/4885 |
| US-12281127-B2 | Pyrido[4,3-d]pyrimidine compounds | DPYD, PNPO, TYMP | MAPT 2869/4885ALDH1A1 436/4885KMT2A 3609/4885 |
| US-20250034173-A1 | PYRIDO[4,3-D]PYRIMIDINE COMPOUNDS | DPYD, PNPO, TYMP | MAPT 2869/4885ALDH1A1 436/4885KMT2A 3609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.