Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 9/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 8/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31552701 | 0.82 | L3MBTL1 (0.53) | CYP11B2CYP19A1CYP11B1MAPTCASP3 | |
| SCHEMBL22043642 | 0.82 | L3MBTL1 (0.53) | CYP11B2CYP19A1CYP11B1MAPTCASP3 | |
| SCHEMBL31127800 | 0.78 | MAPT (0.45) | MAPTCASP3SENP8SENP7SENP6 | |
| SCHEMBL31127751 | 0.78 | MAPT (0.45) | MAPTCASP3SENP8SENP7SENP6 | |
| SCHEMBL24781210 | 0.72 | GPR3 (0.36) | CYP11B2CYP19A1CYP11B1MAPTCASP3 | |
| SCHEMBL23977248 | 0.72 | GPR3 (0.36) | CYP11B2CYP19A1CYP11B1MAPTCASP3 | |
| SCHEMBL30062796 | 0.72 | GPR3 (0.36) | CYP11B2CYP19A1CYP11B1MAPTCASP3 | |
| SCHEMBL315877 | 0.72 | MAOA (0.61) | SRD5A1MAOAMAOBKMT2AMEN1 | |
| SCHEMBL23678473 | 0.70 | CYP11B2 (0.41) | CYP11B2CYP19A1CYP11B1SRD5A1 | |
| SCHEMBL354708 | 0.70 | HTT (0.62) | CYP11B2CYP19A1CYP11B1SRD5A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021217508-A1 | COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF HIF2α AND THEIR METHODS OF USE | NOVARTIS AG (CH) | 2021-11-04 | — | — | WO | disclosed |