Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SPR | P35270 | 2/20 | 0.44 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31133057 | 0.80 | KMT2A (0.59) | GPR119KDM4ETRPV6MAPTTHRB | |
| SCHEMBL27143853 | 0.80 | KDM4E (0.50) | GPR119KDM4ESPRHSD11B1USP30 | |
| SCHEMBL31132453 | 0.77 | SETD7 (0.61) | GPR119KDM4ESPRTRPV6HPGD | |
| Hydrochloric Acid SCHEMBL30020380 | 0.76 | KDM4E (0.47) | GPR119KDM4ESPRHSD11B1USP30 | |
| SCHEMBL27150678 | 0.76 | KDM4E (0.44) | GPR119KDM4ESPRHSD11B1USP30 | |
| SCHEMBL31133156 | 0.74 | TRPV6 (0.50) | KDM4ETRPV6HPGDMAPTKMT2A | |
| SCHEMBL31132494 | 0.73 | GPR119 (0.47) | GPR119KDM4ESPRTRPV6MAPT | |
| SCHEMBL31132989 | 0.72 | GPR119 (0.46) | GPR119KDM4ESPRTRPV6USP30 | |
| SCHEMBL21526591 | 0.71 | HSD11B1 (0.48) | GPR119SPRHSD11B1KMT2AMEN1 | |
| SCHEMBL31267584 | 0.71 | HSD11B1 (0.48) | GPR119SPRHSD11B1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704830-A2 | MRGPRX2 INHIBITORS AND METHODS OF USE THEREOF | Septerna, Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024226914-A2 | MRGPRX2 ANTAGONISTS AND METHODS OF USE THEREOF | SEPTERNA, INC. (US) | 2024-10-31 | — | — | WO | disclosed |