Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA2 | P47869 | 9/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | DUT | P33316 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31132914 | 0.86 | DUT (0.37) | DUT | |
| SCHEMBL31132987 | 0.78 | DUT (0.39) | DUT | |
| SCHEMBL31132944 | 0.73 | ALDH1A1 (0.53) | GABRA2GABRB2GAAKDM4EALDH1A1 | |
| SCHEMBL21809657 | 0.72 | KMT2A (0.37) | GAAKDM4EALDH1A1HPGDDUT | |
| SCHEMBL26631687 | 0.70 | DUT (0.38) | DUTRXFP1 | |
| SCHEMBL6077974 | 0.70 | KMT2A (0.38) | GAAKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL31132827 | 0.69 | DUT (0.38) | GAAKDM4EDUTMAPK1KMT2A | |
| SCHEMBL2928812 | 0.69 | ALDH1A1 (0.43) | GAAKDM4EPOLBALDH1A1CYP1A2 | |
| SCHEMBL13860366 | 0.68 | L3MBTL1 (0.43) | KDM4EALDH1A1HPGDCYP1A2DUT | |
| SCHEMBL2617374 | 0.67 | TARBP2 (0.42) | GABRA2GABRB2KDM4ECYP1A2DUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704830-A2 | MRGPRX2 INHIBITORS AND METHODS OF USE THEREOF | Septerna, Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024226914-A2 | MRGPRX2 ANTAGONISTS AND METHODS OF USE THEREOF | SEPTERNA, INC. (US) | 2024-10-31 | — | — | WO | disclosed |