Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 7/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GCK | P35557 | 3/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30899660 | 0.86 | MRGPRX2 (0.48) | HSD17B10HPGDABL1ADORA3ADORA1 | |
| SCHEMBL27211501 | 0.80 | MRGPRX2 (0.43) | MRGPRX2RAB9AGCK | |
| SCHEMBL29563814 | 0.80 | MRGPRX2 (0.43) | MRGPRX2RAB9AGCK | |
| SCHEMBL31132457 | 0.80 | MRGPRX2 (0.43) | MRGPRX2RAB9AGCK | |
| SCHEMBL29806041 | 0.78 | ABL1 (0.46) | HSD17B10ABL1ADORA3ADORA1ADORA2A | |
| SCHEMBL17778922 | 0.76 | ADORA3 (0.45) | HSD17B10HPGDABL1ADORA3ADORA1 | |
| SCHEMBL18896187 | 0.76 | ADORA3 (0.48) | HSD17B10HPGDADORA3ADORA1ADORA2A | |
| SCHEMBL30899659 | 0.75 | HSD17B10 (0.49) | HSD17B10HPGDADORA3ADORA1ADORA2A | |
| SCHEMBL24298068 | 0.74 | MRGPRX2 (0.48) | MRGPRX2 | |
| SCHEMBL31133251 | 0.70 | MRGPRX2 (0.48) | MRGPRX2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704830-A2 | MRGPRX2 INHIBITORS AND METHODS OF USE THEREOF | Septerna, Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024226914-A2 | MRGPRX2 ANTAGONISTS AND METHODS OF USE THEREOF | SEPTERNA, INC. (US) | 2024-10-31 | — | — | WO | disclosed |