Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NQO2 | P16083 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31133002 | 1.00 | MRGPRX4 (0.36) | MRGPRX4MAPTALDH1A1TSHRGAA | |
| SCHEMBL31133153 | 0.86 | MRGPRX4 (0.34) | MRGPRX4MAPTALDH1A1LMNATP53 | |
| SCHEMBL31132999 | 0.86 | MRGPRX4 (0.34) | MRGPRX4MAPTALDH1A1LMNATP53 | |
| SCHEMBL24769678 | 0.79 | ALDH1A1 (0.43) | MRGPRX4MAPTALDH1A1TSHRGAA | |
| SCHEMBL30017097 | 0.79 | ALDH1A1 (0.40) | MRGPRX4MAPTALDH1A1TSHRGAA | |
| SCHEMBL24770163 | 0.79 | ALDH1A1 (0.40) | MRGPRX4MAPTALDH1A1TSHRGAA | |
| SCHEMBL4918571 | 0.77 | CYP4F2 (0.39) | MRGPRX4MAPTALDH1A1TSHRGAA | |
| SCHEMBL14966057 | 0.76 | PTGES (0.39) | MRGPRX4MAPTALDH1A1TSHRGAA | |
| SCHEMBL336341 | 0.75 | MRGPRX4 (0.34) | MRGPRX4ALDH1A1CNR2KMT2ATP53 | |
| SCHEMBL14969463 | 0.74 | ATR (0.48) | TSHRATRLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4704830-A2 | MRGPRX2 INHIBITORS AND METHODS OF USE THEREOF | Septerna, Inc. (US) | 2026-03-11 | — | — | EP | disclosed |
| WO-2024226914-A2 | MRGPRX2 ANTAGONISTS AND METHODS OF USE THEREOF | SEPTERNA, INC. (US) | 2024-10-31 | — | — | WO | disclosed |