Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 14/20 | 0.50 |
| ▸ | CRBN | Q96SW2 | 14/20 | 0.50 |
| ▸ | BACE1 | P56817 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31727394 | 0.92 | DDB1 (0.42) | DDB1CRBNBACE1 | |
| SCHEMBL29079563 | 0.83 | EPHX2 (0.46) | DDB1CRBN | |
| SCHEMBL31134471 | 0.82 | DDB1 (0.47) | DDB1CRBN | |
| SCHEMBL29079553 | 0.82 | KDM1A (0.42) | DDB1CRBN | |
| SCHEMBL29079577 | 0.80 | DDB1 (0.40) | DDB1CRBNTHRBMAPT | |
| Trifluoroacetic Acid SCHEMBL31727208 | 0.80 | CRBN (0.37) | DDB1CRBN | |
| SCHEMBL25141452 | 0.79 | DDB1 (0.53) | DDB1CRBNBACE1TP53THRB | |
| SCHEMBL31726950 | 0.79 | ALDH1A1 (0.34) | DDB1CRBNMAPT | |
| SCHEMBL30574619 | 0.79 | DDB1 (0.42) | DDB1CRBN | |
| SCHEMBL31152840 | 0.79 | DDB1 (0.49) | DDB1CRBNBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688149-A1 | IRAK4 PROTACS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| US-20240374588-A1 | IRAK4 PROTACS | ASTRAZENECA AB (SE) | 2024-11-14 | — | — | US | disclosed |
| WO-2024209044-A1 | IRAK4 PROTACS | ASTRAZENECA AB (SE) | 2024-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240374588-A1 | IRAK4 PROTACS | IRAK4, IRAK2, IRAK3 | DDB1 728/4885CRBN 99/4885BACE1 1817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.