Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | QPCT | Q16769 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312214 | 0.92 | HPGD (0.47) | AKR1B1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL312401 | 0.89 | KDM4E (0.59) | HPGDMEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL312223 | 0.84 | AKR1B1 (0.56) | AKR1B1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL311987 | 0.82 | ATM (0.50) | HPGDMEN1KMT2ASMN1; SMN2ALOX15 | |
| SCHEMBL311535 | 0.81 | HPGD (0.44) | HPGDMEN1KMT2ATP53ALOX15 | |
| SCHEMBL312841 | 0.81 | AKR1B1 (0.50) | AKR1B1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL311390 | 0.80 | AKR1B1 (0.41) | AKR1B1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL312716 | 0.78 | MAOB (0.43) | AKR1B1HPGDSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL311620 | 0.77 | AKR1B1 (0.43) | AKR1B1HPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL324201 | 0.76 | HPGD (0.61) | AKR1B1HPGDMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093273-B2 | Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2012-01-10 | — | — | US | disclosed |
| EP-2332527-A2 | Flavanoids and Isoflavanoids for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP. (CA) | 2011-06-15 | — | — | EP | disclosed |