Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.51 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.51 |
| ▸ | PNMT | P11086 | 1/20 | 0.50 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.41 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15335678 | 1.00 | CYP11B1 (0.51) | CYP11B1CYP11B2PNMTSRD5A1KDM1A | |
| SCHEMBL15335680 | 1.00 | CYP11B1 (0.51) | CYP11B1CYP11B2PNMTSRD5A1KDM1A | |
| SCHEMBL15086540 | 0.90 | PNMT (0.53) | CYP11B1CYP11B2PNMTSRD5A1KDM1A | |
| SCHEMBL29495985 | 0.90 | PNMT (0.53) | CYP11B1CYP11B2PNMTSRD5A1KDM1A | |
| SCHEMBL1863996 | 0.90 | PNMT (0.53) | CYP11B1CYP11B2PNMTSRD5A1KDM1A | |
| SCHEMBL24452647 | 0.90 | PNMT (0.53) | CYP11B1CYP11B2PNMTSRD5A1KDM1A | |
| Hydrochloric Acid SCHEMBL3588397 | 0.88 | PNMT (0.51) | CYP11B1CYP11B2PNMTSRD5A1KDM1A | |
| Hydrochloric Acid SCHEMBL16536351 | 0.88 | PNMT (0.51) | CYP11B1CYP11B2PNMTSRD5A1KDM1A | |
| SCHEMBL15336335 | 0.87 | CYP11B1 (0.51) | CYP11B1CYP11B2PNMTKDM1ANOS3 | |
| SCHEMBL15336336 | 0.87 | CYP11B1 (0.51) | CYP11B1CYP11B2PNMTKDM1ANOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250388585-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES INC (US) | 2025-12-25 | — | — | US | disclosed |
| US-12448388-B2 | PRMT5 inhibitors and uses thereof | GILEAD SCIENCES, INC. (US) | 2025-10-21 | — | — | US | disclosed |
| US-20240376110-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. | 2024-11-14 | — | — | US | disclosed |
| WO-2024220917-A1 | PRMT5 INHIBITORS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2024-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250388585-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT1, PRMT5, PRMT6 | CYP11B1 1569/4885CYP11B2 2244/4885PNMT 815/4885 |
| US-20240376110-A1 | PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT9 | CYP11B1 1825/4885CYP11B2 2085/4885PNMT 217/4885 |
| US-12448388-B2 | PRMT5 inhibitors and uses thereof | PRMT5, PRMT1, PRMT9 | CYP11B1 1825/4885CYP11B2 2085/4885PNMT 217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.