Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553080 | 0.87 | CYP2A13 (0.50) | TSHRPOLBKMT2ADRD2DRD4 | |
| SCHEMBL12108587 | 0.78 | HDAC1 (0.40) | TP53HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL22391824 | 0.75 | GRM2 (0.43) | TP53HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9147970 | 0.74 | TSHR (0.58) | HTR1ATSHRKMT2AGRM5HPGD | |
| SCHEMBL28892515 | 0.72 | POLB (0.52) | HTR1ATSHRPOLBKMT2AGRM5 | |
| SCHEMBL30002695 | 0.72 | POLB (0.52) | HTR1ATSHRPOLBKMT2AGRM5 | |
| SCHEMBL18783813 | 0.71 | PTGIR (0.43) | — | |
| SCHEMBL22391952 | 0.70 | HTR3A (0.45) | TP53HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL28238549 | 0.70 | HDAC1 (0.56) | HTR1ATSHRPOLBKMT2AGRM5 | |
| SCHEMBL2208731 | 0.70 | HDAC1 (0.53) | HTR1ATSHRPOLBKMT2AGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568664-A1 | COMBINATION COMPRISING A THR-BETA AGONIST AND A GLP-1R AGONIST FOR USE IN TREATING A LIVER DISORDER OR A CARDIOMETABOLIC DISEASE | Terns Pharmaceuticals, Inc. (US) | 2025-06-18 | — | — | EP | disclosed |
| WO-2024211898-A1 | COMBINATION COMPRISING A THRBETA AGONIST ANDA GLP-1R AGONIST FOR USE IN TREATING A LIVER DISORDER OR A CARDIOMETABOLIC DISEASE | TERNS PHARMACEUTICALS, INC. (US) | 2024-10-10 | — | — | WO | disclosed |