Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 6/20 | 0.36 |
| ▸ | CDK9 | P50750 | 5/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.32 |
| ▸ | GPR6 | P46095 | 3/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | CASP7 | P55210 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31146155 | 0.85 | PDE2A (0.36) | PDE2ACDK9CCNT1GPR6IDH1 | |
| SCHEMBL31145974 | 0.85 | PDE2A (0.36) | PDE2ACDK9CCNT1GPR6IDH1 | |
| SCHEMBL31146221 | 0.80 | MAPK1 (0.36) | PDE2AIDH1MAPK1GPR139 | |
| SCHEMBL31146023 | 0.73 | PDE2A (0.34) | PDE2AMAPK1GPR139 | |
| SCHEMBL31161025 | 0.73 | MAPK1 (0.37) | PDE2AMAPK1GPR139 | |
| SCHEMBL31359129 | 0.71 | GPR139 (0.45) | GPR139 | |
| SCHEMBL31146104 | 0.71 | GPR139 (0.40) | PDE2AIDH1MAPK1GPR139 | |
| SCHEMBL31146209 | 0.71 | LRRK2 (0.35) | IDH1IDO1 | |
| SCHEMBL31146394 | 0.70 | PDE2A (0.38) | PDE2AMAPK1GPR139 | |
| SCHEMBL31145941 | 0.69 | IDO1 (0.35) | CDK9CCNT1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688748-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024206339-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-10-03 | — | — | WO | disclosed |