Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 7/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NEK1 | Q96PY6 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31146221 | 0.86 | MAPK1 (0.36) | PDE2AGPR139BRD4PPARGMAPK1 | |
| SCHEMBL31146204 | 0.78 | S1PR3 (0.35) | — | |
| SCHEMBL31145972 | 0.73 | PDE2A (0.36) | PDE2AGPR139MAPK1 | |
| SCHEMBL31358977 | 0.71 | GPR139 (0.38) | PDE2AGPR139KDM4E | |
| SCHEMBL31359024 | 0.71 | GPR139 (0.38) | PDE2AGPR139KDM4E | |
| SCHEMBL31161025 | 0.70 | MAPK1 (0.37) | PDE2AGPR139MAPK1KDM4E | |
| SCHEMBL31358980 | 0.70 | GPR139 (0.47) | GPR139PPARGKDM4E | |
| SCHEMBL8300134 | 0.67 | CES2 (0.44) | PDE2AGPR139PPARG | |
| SCHEMBL31359082 | 0.67 | L3MBTL1 (0.48) | GPR139PPARG | |
| SCHEMBL31187732 | 0.67 | L3MBTL1 (0.48) | GPR139PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688748-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2026-02-11 | — | — | EP | disclosed |
| WO-2024206339-A1 | QUINOLINONE AMIDE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2024-10-03 | — | — | WO | disclosed |