Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.33 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2763256 | 0.75 | KCNN4 (0.39) | KCNH2ALOX15ALDH1A1KIF11KCNN4 | |
| SCHEMBL21579326 | 0.74 | TSHR (0.41) | CHRM2TSHRGABRA5BLMKCNH2 | |
| SCHEMBL9289408 | 0.73 | KCNN4 (0.41) | CYP3A4ALOX15ALDH1A1CYP2D6KIF11 | |
| SCHEMBL290393 | 0.73 | TSHR (0.37) | TSHRGABRA5BLMKCNH2NPC1 | |
| SCHEMBL9288039 | 0.71 | KCNN4 (0.42) | KCNH2ALOX15ALDH1A1CYP2D6KIF11 | |
| SCHEMBL5520187 | 0.71 | TSHR (0.43) | TSHRNPC1ALDH1A1LMNACYP1A2 | |
| SCHEMBL6825891 | 0.70 | SCN4A (0.39) | TSHRALOX15NPC1ALDH1A1KDM4E | |
| SCHEMBL3369844 | 0.70 | TSHR (0.48) | TSHRNPC1ALDH1A1LMNACYP1A2 | |
| SCHEMBL10640000 | 0.70 | TSHR (0.36) | TSHRGABRA5ALDH1A1CYP2D6CYP2C19 | |
| Hydrochloric Acid SCHEMBL7409176 | 0.70 | KCNN4 (0.41) | KCNH2ALOX15ALDH1A1KIF11KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10188758-B2 | Organic compounds | INTRA-CELLULAR THERAPIES, INC. (US) | 2019-01-29 | — | — | US | disclosed |
| US-20180099060-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. | 2018-04-12 | — | — | US | disclosed |
| EP-3270920-A1 | ORGANIC COMPOUNDS | Intra-Cellular Therapies, Inc. (US) | 2018-01-24 | — | — | EP | disclosed |
| WO-2016154027-A1 | ORGANIC COMPOUNDS | INTRA-CELLULAR THERAPIES, INC. (US) | 2016-09-29 | — | — | WO | disclosed |
| EP-2161998-B1 | Pyridine derivatives as NET/SERT modulators | INTRA CELLULAR THERAPIES INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-8183266-B2 | Methods | INTRA-CELLULAR THERAPIES, INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20100173951-A1 | NOVEL METHODS | INTRA-CELLULAR THERAPIES, INC. | 2010-07-08 | — | — | US | disclosed |
| EP-2161998-A1 | NOVEL METHODS | Intra-Cellular Therapies, Inc. (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008150528-A1 | NOVEL METHODS | INTRA-CELLULAR THERAPIES, INC. (US) | 2008-12-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10188758-B2 | Organic compounds | SLC6A2, PNMT, SLC6A4 | CHRM2 357/4885TSHR 1576/4885GABRA5 732/4885 |
| US-20100173951-A1 | NOVEL METHODS | SLC6A4, SLC6A2, TPH1 | CHRM2 584/4885TSHR 810/4885GABRA5 513/4885 |
| US-20180099060-A1 | ORGANIC COMPOUNDS | SLC6A2, PNMT, SLC6A4 | CHRM2 357/4885TSHR 1576/4885GABRA5 732/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.