Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20745675 | 1.00 | HPGD (0.45) | HPGDTSHRSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL648200 | 0.85 | CHRNA1 (0.41) | HPGDTSHRRAB9ANPC1ALDH1A1 | |
| SCHEMBL648199 | 0.85 | CHRNA1 (0.41) | HPGDTSHRRAB9ANPC1ALDH1A1 | |
| SCHEMBL19231777 | 0.85 | CHRNA1 (0.41) | HPGDTSHRRAB9ANPC1ALDH1A1 | |
| SCHEMBL20745021 | 0.78 | MAOB (0.33) | TSHRSMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL20745020 | 0.78 | MAOB (0.33) | TSHRSMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL25100436 | 0.78 | CYP2C19 (0.51) | HPGDTSHRSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL3115579 | 0.78 | HPGD (0.42) | HPGDTSHRRAB9ANPC1ALDH1A1 | |
| SCHEMBL5796393 | 0.77 | IDO1 (0.41) | RAB9ANPC1NPSR1 | |
| SCHEMBL4459800 | 0.77 | IDO1 (0.41) | RAB9ANPC1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11589586-B2 | Pesticidal and parasiticidal pyrazole-isoxazoline compounds | Boehringer Ingelheim Animal Health USA Inc. (US) | 2023-02-28 | — | — | US | disclosed |
| EP-3668866-B1 | PESTICIDAL AND PARASITICIDAL PYRAZOLE-ISOXAZOLINE COMPOUNDS | BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC (US) | 2023-01-18 | — | — | EP | disclosed |
| EP-3668866-A1 | PESTICIDAL AND PARASITICIDAL PYRAZOLE-ISOXAZOLINE COMPOUNDS | Boehringer Ingelheim Animal Health USA Inc. (US) | 2020-06-24 | — | — | EP | disclosed |
| US-20200178531-A1 | PESTICIDAL AND PARASITICIDAL PYRAZOLE-ISOXAZOLINE COMPOUNDS | Boehringer Ingelheim Animal Health USA Inc. (US) | 2020-06-11 | — | — | US | disclosed |
| WO-2019036407-A1 | PESTICIDAL AND PARASITICIDAL PYRAZOLE-ISOXAZOLINE COMPOUNDS | MERIAL, INC. (US) | 2019-02-21 | — | — | WO | disclosed |
| US-8372867-B2 | Insecticidal aryl isoxazoline derivatives | BAYER CROPSCIENCE AG (DE) | 2013-02-12 | — | — | US | disclosed |
| US-20100179194-A1 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | BAYER CORPSCIENCE AG (DE) | 2010-07-15 | — | — | US | disclosed |
| EP-2181100-A2 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | Bayer CropScience AG (DE) | 2010-05-05 | — | — | EP | disclosed |
| WO-2008122375-A2 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11589586-B2 | Pesticidal and parasiticidal pyrazole-isoxazoline compounds | PRDX1, PRDX5, P2RX7 | HPGD 1900/4885TSHR 1228/4885SMN1; SMN2 4050/4885 |
| US-20100179194-A1 | INSECTICIDAL ARYL ISOXAZOLINE DERIVATIVES | CYP4X1, AADAC, CYP3A7 | HPGD 3135/4885TSHR 953/4885SMN1; SMN2 3513/4885 |
| US-20200178531-A1 | PESTICIDAL AND PARASITICIDAL PYRAZOLE-ISOXAZOLINE COMPOUNDS | PRDX1, PRDX5, P2RX7 | HPGD 1900/4885TSHR 1228/4885SMN1; SMN2 4050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.