Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 13/20 | 0.88 |
| ▸ | ADORA1 | P30542 | 13/20 | 0.88 |
| ▸ | ADORA2B | P29275 | 6/20 | 0.88 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.56 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL3118523 | 0.97 | ADORA2A (0.90) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL3118879 | 0.94 | ADORA2A (0.84) | ADORA2AADORA1ADORA2BADORA3BRD4 | |
| SCHEMBL1553927 | 0.94 | ADORA2A (1.00) | ADORA2AADORA1ADORA2BADORA3 | |
| Hydrochloric Acid SCHEMBL3111468 | 0.93 | ADORA2A (0.98) | ADORA2AADORA1ADORA2BADORA3 | |
| Water SCHEMBL2958593 | 0.93 | ADORA2A (0.98) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL3114718 | 0.91 | ADORA2A (0.80) | ADORA2AADORA1ADORA2BADORA3 | |
| Phosphoric Acid SCHEMBL3111633 | 0.91 | ADORA2A (0.90) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL3111625 | 0.90 | ADORA2A (0.77) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL21176829 | 0.81 | ADORA2A (0.76) | ADORA2AADORA1ADORA2BADORA3 | |
| SCHEMBL1553621 | 0.80 | ADORA2A (0.75) | ADORA2AADORA1ADORA2BADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179321-A1 | SALT OF 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1-METHYLPYRIDIN-2(1H)-ONE AND CRYSTAL THEREOF | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179321-A1 | SALT OF 5-[2-AMINO-4-(2-FURYL)PYRIMIDIN-5-YL]-1-METHYLPYRIDIN-2(1H)-ONE AND CRYSTAL THEREOF | SLC28A1, SLC28A2, SLC20A1 | ADORA2A 2391/4885ADORA1 1669/4885ADORA2B 3904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.